dc.contributor.author | Bekircan, Olcay | |
dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Ülker, Serdar | |
dc.date.accessioned | 2020-12-19T20:03:00Z | |
dc.date.available | 2020-12-19T20:03:00Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Bekircan, O., Mentese, E., Ulker, S. (2014). Synthesis and pharmacological activities of some new 2-[1-Heptyl-3-(4-methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl] acetohydrazide derivatives. Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences, 69(9-10), 969-981. https://doi.org/10.5560/ZNB.2014-4126 | en_US |
dc.identifier.issn | 0932-0776 | |
dc.identifier.issn | 1865-7117 | |
dc.identifier.uri | https://doi.org/10.5560/ZNB.2014-4126 | |
dc.identifier.uri | https://hdl.handle.net/11436/3057 | |
dc.description | WOS: 000347145200004 | en_US |
dc.description.abstract | In the present investigation, the key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f and arylidenehydrazide derivatives 8a-d were obtained from compound 5. the cyclization of compounds 6a-f in the presence of NaOH resulted in the formation of compounds 7a-f. the compounds were characterized by IR, H-1 NMR, C-13 NMR spectroscopy, elemental analysis and mass spectial studies. the compounds were tested for their anti-lipase, anti-alpha-glucosidase and anti-mycobacterial activities. Compounds 6b and 8c exhibited excellent anti-lipase activity, and compound 8d showed excellent anti-alpha-glucosidase activity. Compounds 3 and 4 exhibited good anti-tuberculosis activity. | en_US |
dc.description.sponsorship | Karadeniz Technical University, BAP, TurkeyKaradeniz Technical University [10020] | en_US |
dc.description.sponsorship | The support provided by Karadeniz Technical University, BAP, Turkey (project no. 10020) is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Walter de Gruyter Gmbh | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acetohydrazide Derivatives | en_US |
dc.subject | 1,2,4-Triazoles | en_US |
dc.subject | 1,2,4-Triazole-5-thiones | en_US |
dc.subject | Lipase and alpha-Glucosidase Inhibitor Activities | en_US |
dc.subject | Anti-mycobacterial Activity | en_US |
dc.title | Synthesis and pharmacological activities of some new 2-[1-Heptyl-3-(4-methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl] acetohydrazide derivatives | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.identifier.doi | 10.5560/ZNB.2014-4126 | |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 09.Oct | en_US |
dc.identifier.startpage | 969 | en_US |
dc.identifier.endpage | 981 | en_US |
dc.relation.journal | Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |