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The effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacin

dc.contributor.authorYılmaz, İsmayıl
dc.contributor.authorDemiryılmaz, İsmail
dc.contributor.authorŞener, Ebru
dc.contributor.authorÇetin, Nihal
dc.contributor.authorÜçüncü, Yılmaz
dc.contributor.authorAltuner, Durdu
dc.contributor.authorKurt, Nezahat
dc.contributor.authorKunak, Semih C.
dc.contributor.authorKısaoğlu, Abdullah
dc.contributor.authorÖzoğul, Bünyamin
dc.contributor.authorSüleyman, Halis
dc.date.accessioned2020-12-19T20:03:35Z
dc.date.available2020-12-19T20:03:35Z
dc.date.issued2014
dc.identifier.citationYilmaz, I., Demiryilmaz, I., Sener, E., Cetin, N., Ucuncu, Y., Altuner, D., Ucuncu, Y. (2014). The effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacin. Latin American Journal of Pharmacy, 33(3), 453-458.en_US
dc.identifier.issn0326-2383
dc.identifier.urihttps://hdl.handle.net/11436/3200
dc.descriptionKurt, Nezahat/0000-0002-1685-5332; Cetin, Nihal/0000-0003-3233-8009en_US
dc.descriptionWOS: 000337943300014en_US
dc.description.abstractThe effect of Hippophae rhamnoides (HR) extract on oxidative damage on rat's gastric tissue depending on co-implementation of methotrexate (MTX) and indomethacin (IND) was investigated biochemically and histopathologically. HR extract was given to HR extract-given (HRIM) group of rats with dose of 50 mg/kg, and to IND+MTX-implemented rat group (IMG) orally with distilled water through catheter. One hour after, IND and MTX combination was given to HRIM and IMG groups orally for 7 days with dose of 5 mg/kg. in gastric tissues of IMG group, the MDA amount increased to healthy-sham (SG) and HRIM groups. the amount of tGSH, in IMG group's gastric tissue decreased to SG and HRIM groups. Serious focal erosions, sub-mucosal edemas and mixed-type inflammatory cell infiltrations have been observed on surface epithelium of histopathological sections of stomachs of IMG group. HR extract prevent the gastric damage in rats' gastric tissues, which was formed by MTX and IND combination.en_US
dc.language.isoengen_US
dc.publisherColegio Farmaceuticos Provincia de Buenos Airesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric tissueen_US
dc.subjectHippophae rhamnoidesen_US
dc.subjectIndomethacinen_US
dc.subjectMethotrexateen_US
dc.subjectRaten_US
dc.titleThe effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacinen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorÇetin, Nihal
dc.contributor.institutionauthorÜçüncü, Yılmaz
dc.contributor.institutionauthorAltuner, Durdu
dc.contributor.institutionauthorSüleyman, Halis
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.startpage453en_US
dc.identifier.endpage458en_US
dc.relation.journalLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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