dc.contributor.author | Çiçek, Ayşegül Çopur | |
dc.contributor.author | Saral, Ayşegül | |
dc.contributor.author | Düzgün, Azer Özad | |
dc.contributor.author | Yaşar, Ekrem | |
dc.contributor.author | Çizmeci, Zeynep | |
dc.contributor.author | Balcı, Pervin Özlem | |
dc.contributor.author | Sarı, Fatma | |
dc.contributor.author | Fırat, Mehmet | |
dc.contributor.author | Altıntop, Yasemin Ay | |
dc.contributor.author | Ak, Sibel | |
dc.contributor.author | Çalışkan, Ahmet | |
dc.contributor.author | Yıldız, Nazan | |
dc.contributor.author | Sancaktar, Metin | |
dc.contributor.author | Budak, Emine Esra | |
dc.contributor.author | Ertürk, Ayşe | |
dc.contributor.author | Özgüm, Osman Birol | |
dc.contributor.author | Sandallı, Cemal | |
dc.date.accessioned | 2020-12-19T20:03:55Z | |
dc.date.available | 2020-12-19T20:03:55Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Çiçek, AC., Saral, A., Düzgün, AO., Yaşar, E., Çizmeci, Z., Balcı, PO. ve diğerleri. (2013). Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey. Journal of Antibiotics, 66(11), 647-650. | en_US |
dc.identifier.issn | 0021-8820 | |
dc.identifier.issn | 1881-1469 | |
dc.identifier.uri | https://doi.org/10.1038/ja.2013.72 | |
dc.identifier.uri | https://hdl.handle.net/11436/3252 | |
dc.description | DUZGUN, AZER OZAD/0000-0002-6301-611X; DUZGUN, AZER OZAD/0000-0002-6301-611X; Ay Altintop, Yasemin/0000-0002-6586-5561 | en_US |
dc.description | WOS: 000327677600003 | en_US |
dc.description.abstract | Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), blood (6.59%), cerebrospinal fluid (1.13%), pleural fluid (2.95%), wound (4.31%) and sputum (4.54%). ESBL-coding genes (CTX-M1, CTX-M2, TEM, SHV) were detected by PCR. According to the PCR and sequencing results, CTX-M1 was the most prevalent beta-lactamase 83.18% (366/440), followed by TEM 44.09% (194/440), CTX-M2 31.81% (140/440) and SHV 1.81% (8/440). Sequencing results showed that TEM and SHV types were TEM-1b and SHV-11, respectively. Rate of the strains harboring only CTX-M1, CTX-M2,TEM-1b and SHV-11 were 30.90%, 3.63%, 2.27% and 0.23%, respectively. Rate of the strains harboring the combinations of CTX-M1-CTX-M2, CTX-M1-CTX-M2-TEM-1b, CTX-M2-TEM-1b, CTX-M1-TEM-1b, CTX-M1-CTX-M2-TEM-1b-SHV-11, CTX-M1-TEM-1b-SHV-11, CTX-M1-SHV-11, CTX-M1-CTX-M2-SHV-11, CTX-M2-SHV-11, CTX-M2-TEM-1b-SHV-11, TEM-1b-SHV-11 were 12.95%, 11.59%, 2.95%, 26.13%, 0.45%, 0.68%, 0.22%, 0.22%, 0%, 0% and 0%, respectively. This is a nationwide study of ESBL-producing E. coli in Turkey. These results shows that CTX-M1 group is the most common type of class A beta-lactamases among ESBL-producing E. coli strains in Turkey. | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan University [BAP-2012.106.01.11, BAP-2011.102.03.3] | en_US |
dc.description.sponsorship | This work was supported by Recep Tayyip Erdogan University Research Fund Grants BAP-2012.106.01.11 and BAP-2011.102.03.3. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Beta-Lactamase | en_US |
dc.subject | CTX-M1 | en_US |
dc.subject | CTX-M2 | en_US |
dc.subject | SHV-11 | en_US |
dc.subject | TEM-1b | en_US |
dc.title | Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Çiçek, Ayşegül Çopur | |
dc.contributor.institutionauthor | Özgüm, Osman Birol | |
dc.contributor.institutionauthor | Sandallı, Cemal | |
dc.identifier.doi | 10.1038/ja.2013.72 | |
dc.identifier.volume | 66 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 647 | en_US |
dc.identifier.endpage | 650 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Journal of Antibiotics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |