Investigating the effect of prunus laurocerasus fruit extract in type II diabetes induced rats

Abstract

Prunus laurocerasus (PL) is the fruits of the officinalis species in the Rosaceae family. It is used as diuretic, antidiabetic, antiulcer, dermatitis and hemorrhoids. This study investigate the antidiabetic effects of PL fruit extracts. Study was carried out at three stage. First; the effect of PL fruit extract (500 and 1000 mg kg(-1) dose levels) was investigated in diabetic rats induced with alloxan and compared with gliclazide. Furthermore, the effect of PL extract on postprandial blood levels and hypoglycemia induced by gliclazide were investigated. Experimental results showed that PL extract lowered the blood glucose levels significantly at 500 and 1000 mg kg(-1) dose levels. on the other hand, PL extract brought the blood levels to a normal after gliclazide induced hypoglycemia. the PL extract was found to be an agent with agonist-antagonist properties. the results indicate that PL extract can be used in patients both with hypoglycemia and hyperglycemia.