dc.contributor.author | Kahveci, Bahittin | |
dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Özil, Musa | |
dc.contributor.author | Ülker, Serdar | |
dc.contributor.author | Ertürk, Murat | |
dc.date.accessioned | 2020-12-19T20:04:22Z | |
dc.date.available | 2020-12-19T20:04:22Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Kahveci, B., Mentese, E., Ozil, M., Ulker, S., Erturk, M. (2013). An efficient synthesis of benzimidazoles via a microwave technique and evaluation of their biological activities. Monatshefte Fur Chemie, 144(7), 993-1001. https://doi.org/10.1007/s00706-012-0916-0 | en_US |
dc.identifier.issn | 0026-9247 | |
dc.identifier.issn | 1434-4475 | |
dc.identifier.uri | https://doi.org/10.1007/s00706-012-0916-0 | |
dc.identifier.uri | https://hdl.handle.net/11436/3320 | |
dc.description | Ozil, Musa/0000-0002-1980-1364 | en_US |
dc.description | WOS: 000320406300011 | en_US |
dc.description.abstract | A simple and practical protocol was developed for the synthesis of benzimidazoles. the protocol uses iminoester hydrochloride which is very useful in the reaction with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leading to the products with good yields and in short reaction times. This method can be used as a general technique for synthesizing benzimidazoles. the synthesized compounds were evaluated for their biological properties such as anti-lipase, antiviral, and antitumor activities. Five benzimidazol-1-acetic acid hydrazides showed slight antiviral activity at 25 mu g/cm(3) concentration despite their low toxicity. Substituted 2-benzylbenzimidazoles were active against adenocarcinoma (CT26) and melanoma (B16F10) cancer cell lines at concentrations below 10 mu g/cm(3). Six of the compounds showed anti-lipase activities at various concentrations; the IC50 value of one compound was 0.35 mu g/cm(3), which is similar activity to that of orlistat (0.32 mu g/cm(3)). | en_US |
dc.description.sponsorship | Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108T356] | en_US |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Scientific and Technical Research Council of Turkey (TUBITAK) through Project 108T356. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Wien | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Benzimidazole drug | en_US |
dc.subject | Microwave | en_US |
dc.subject | Iminoester hydrochloride | en_US |
dc.subject | Antitumor activity | en_US |
dc.subject | Anti-lipase activity | en_US |
dc.title | An efficient synthesis of benzimidazoles via a microwave technique and evaluation of their biological activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.contributor.institutionauthor | Özil, Musa | |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.identifier.doi | 10.1007/s00706-012-0916-0 | |
dc.identifier.volume | 144 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 993 | en_US |
dc.identifier.endpage | 1001 | en_US |
dc.relation.journal | Monatshefte Fur Chemie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |