dc.contributor.author | Şatıroğlu, Ömer | |
dc.contributor.author | Uydu, Hüseyin Avni | |
dc.contributor.author | Demir, Adem | |
dc.contributor.author | Bostan, Mehmet | |
dc.contributor.author | Atak, Mehtap | |
dc.contributor.author | Bozkurt, Engin | |
dc.date.accessioned | 2020-12-19T20:10:49Z | |
dc.date.available | 2020-12-19T20:10:49Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Satiroglu, O., Uydu, H. A., Demir, A., Bostan, M., Atak, M., & Bozkurt, E. (2011). Association between plasma monocyte chemoattractant protein-1 levels and the extent of atherosclerotic peripheral artery disease. The Tohoku journal of experimental medicine, 224(4), 301–306. https://doi.org/10.1620/tjem.224.301 | en_US |
dc.identifier.issn | 1349-3329 | |
dc.identifier.uri | https://doi.org/10.1620/tjem.224.301 | |
dc.identifier.uri | https://hdl.handle.net/11436/3576 | |
dc.description | PubMed: 21799302 | en_US |
dc.description.abstract | Peripheral artery disease occurs at advanced ages and accounts for substantial cardiovascular morbidity and mortality. Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). The aim of the current study was to investigate the association between the extent of atherosclerotic peripheral artery disease (PAD) and the increase in MCP-1 level. Eighty consecutive patients who had undergone peripheral angiography for suspected PAD were included. Of these patients, 48 (60%) had hypertension, 23 (28.8%) had type 2 diabetes mellitus, 39 (48.8%) had a family history of coronary artery disease, 23 (28.8%) were cigarette smokers, and 42 (52.5%) had hypercholesterolemia. Angiography revealed that the peripheral arteries of the lower extremity were normal in 41 (51.3%) patients, whereas 39 (48.7%) patients had varying degrees of PAD. The patients were queried regarding age, gender, and atherosclerotic risk factors. The plasma MCP-1 levels were significantly lower in the patients without PAD than those in the patients with PAD (172.27 ± 38.05 pg/mL vs. 200.87 ± 39.31 pg/mL, p = 0.001). Moreover, as the severity of PAD increases, MCP-1 levels also increase. Thus, the plasma MCP-1 level can be used in the diagnosis of PAD and in determining the extent of atherosclerotic PAD of the lower extremities, as in determining the extent of coronary artery disease. © 2011 Tohoku University Medical Press | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Association between plasma monocyte chemoattractant protein-1 levels and the extent of atherosclerotic peripheral artery disease | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Şatıroğlu, Ömer | |
dc.contributor.institutionauthor | Uydu, Hüseyin Avni | |
dc.contributor.institutionauthor | Demir, Adem | |
dc.contributor.institutionauthor | Bostan, Mehmet | |
dc.contributor.institutionauthor | Atak, Mehtap | |
dc.contributor.institutionauthor | Bozkurt, Engin | |
dc.identifier.doi | 10.1620/tjem.224.301 | |
dc.identifier.volume | 224 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 301 | en_US |
dc.identifier.endpage | 306 | en_US |
dc.relation.journal | The Tohoku journal of experimental medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |