dc.contributor.author | Bostan, Habib | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Tomak, Yakup | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Altuner, Durdu | |
dc.contributor.author | Yılmaz, Adnan | |
dc.contributor.author | Erdivanlı, Başar | |
dc.contributor.author | Bedir, Recep | |
dc.date.accessioned | 2020-12-19T20:10:52Z | |
dc.date.available | 2020-12-19T20:10:52Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Bostan, H., Kalkan, Y., Tomak, Y., Tumkaya, L., Altuner, D., Yılmaz, A., Erdivanli, B., & Bedir, R. (2011). Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys. Renal failure, 33(10), 1019–1024. https://doi.org/10.3109/0886022X.2011.618972 | en_US |
dc.identifier.issn | 0886-022X | |
dc.identifier.uri | https://doi.org/10.3109/0886022X.2011.618972 | |
dc.identifier.uri | https://hdl.handle.net/11436/3595 | |
dc.description | PubMed: 22013936 | en_US |
dc.description.abstract | Background: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six Sprague-Dawley male rats were divided to receive intravenously 16 or 96 mg/kg sugammadex, 1 mg/kg rocuronium, 1 mg/kg rocuronium + 16 mg/kg sugammadex, or 1 mg/kg rocuronium + 96 mg/kg sugammadex. The control group received an equal volume of physiological serum. Rats receiving rocuronium were ventilated until resumption of spontaneous ventilation and followed for 72 h. Blood samples were withdrawn from the tail vein to measure urea, creatinine, and electrolyte values; then both kidneys were excised, and the tissues were used for histopathological examination. Results: Rats receiving rocuronium and high doses of sugammadex (96 mg/kg) showed increased glomerular vacuolation, tubular dilatation, vascular vacuolation and hypertrophy, lymphocyte infiltration, and tubular cell sloughing compared to the control group (p = 0.002). Biochemical markers of renal function were not significantly altered after treatment with high doses of sugammadex. Conclusion: The elimination half-life of the rocuroniumsugammadex complex was found to be greater than that of free rocuronium or sugammadex, which led to marginal histopathological changes in the kidney without affecting any renal functions. © 2011 Informa Healthcare USA, Inc. | en_US |
dc.description.sponsorship | This work was supported by all authors with no external funding from a government agency or company. The animals, materials, and drugs were provided by the first author as research fund from his institution (Medical Faculty of Rize University, Department of Anesthesiology and Reanimation). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Neuromuscular block | en_US |
dc.subject | Rat | en_US |
dc.subject | Rocuronium | en_US |
dc.subject | Sprague-Dawley | en_US |
dc.subject | Sugammadex | en_US |
dc.title | Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Bostan, Habib | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Tomak, Yakup | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Altuner, Durdu | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.contributor.institutionauthor | Bedir, Recep | |
dc.identifier.doi | 10.3109/0886022X.2011.618972 | |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 1019 | en_US |
dc.identifier.endpage | 1024 | en_US |
dc.relation.journal | Renal Failure | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |