Synthesis of novel triazol compounds containing isatin as potential antibacterial and antifungal agents by microwave and conventional methods
Citation
Özil, M., Menteşe, E., Yılmaz, F., İslamoğlu, F. & Kahveci, B. (2011). Synthesis of novel triazol compounds containing isatin as potential antibacterial and antifungal agents by microwave and conventional methods. Journal of Chemical Research, 35(5), 268-271. https://doi.org/10.3184/174751911X13043524455143Abstract
Microwave irradiation has been used to accelerate the conversion of isatin (1a) and 5-nitroisatin (1b) into their Schiff bases 3-[5?-aryl(alkyl)- 2?,4?-dihydro-1?,2?,4?-triazol-3?-on- 4?-yl]iminoisatin (3a-g) and 3-[5?-aryl(alkyl)-2?,4?- dihydro-1?,2?,4?-triazol-3?-on-4?-yl] imino-5-nitroisatin (4a-g), respectively. Reaction was achieved by microwave-induced technique, which reduced the reaction time drastically and improved the yield when compared to conventional heating. The newly synthesised bases showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested.
