dc.contributor.author | Usta, Asu | |
dc.contributor.author | Yaşar, Ahmet | |
dc.contributor.author | Yılmaz, Nagihan | |
dc.contributor.author | Güleç, Canan | |
dc.contributor.author | Yaylı, Nuran | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Yaylı, Nurettin | |
dc.date.accessioned | 2020-12-19T20:13:02Z | |
dc.date.available | 2020-12-19T20:13:02Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Usta, A., Yaşar, A., Yılmaz, N., Güleç, C., Yaylı, N., Karaoğlu, Ş.A. & Yaylı, N. (2007). Synthesis, Configuration, and Antimicrobial Properties of Novel Substituted and Cyclized ‘2′,3″-Thiazachalcones’. Helvetica Chimica Acta, 90(8), 1482-1490. https://doi.org/10.1002/hlca.200790154 | en_US |
dc.identifier.issn | 0018-019X | |
dc.identifier.uri | https://doi.org/10.1002/hlca.200790154 | |
dc.identifier.uri | https://hdl.handle.net/11436/3964 | |
dc.description.abstract | Nine new thiazachalcone-based drugs, compounds 1-9, were prepared and fully characterized. The configurations of the photochemical-dimerization products 7-9 were rationalized by semi-empirical calculations. Both the experimental data and the theoretical calculations showed that the ?-truxinic acid type dimer is the most stable isomer of all. All compounds were tested for their antibacterial and antifungal activities. The N-alkylated congeners 4-6 showed strong antimicrobial activities against various bacteria and a yeast-like fungus. The MIC and MBC values were as low as 0.1 ?g/ml. All the compounds were active against the Gram-positive bacterium Staphylococcus aureus. © 2007 Verlag Helvetica Chimica Acta AG. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Synthesis, Configuration, and Antimicrobial Properties of Novel Substituted and Cyclized ‘2′,3″-Thiazachalcones’ | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.doi | 10.1002/hlca.200790154 | |
dc.identifier.volume | 90 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 1482 | en_US |
dc.identifier.endpage | 1490 | en_US |
dc.relation.journal | Helvetica Chimica Acta | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |