In vitro antioxidant and acidic properties of novel 4-(5-Methyl- 24hienylmethyleneamino)-4,5-dihydro-1H-l,2,4-triazol-5one derivatives. Synthesis and characterization

Abstract

In the present study 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-l,2,4-triazol-5- ones 2a-i reacted with 5-methylthiophene-2-carboxyaldehyde to afford the corresponding compounds 3a-i and the acetylation reactions of compounds 3a, 3b, 3d, 3g and 3i were investigated. The structures of fourteen new compounds are established from the spectral data. The synthesized 3 and 4 type compounds were analyzed for their in vitro potential antioxidant activities by three different methods. Besides, compounds 3a-i were titrated potentiometrically with tetrabutylammonium hydroxide in four nonaqueous solvents.