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dc.contributor.authorÇiçek, Yüksel
dc.contributor.authorKocaman, Sinan Altan
dc.contributor.authorDurakoğlugil, Murtaza Emre
dc.contributor.authorÇetin, Mustafa
dc.contributor.authorÇanga, Aytun
dc.contributor.authorBozok, Şahin
dc.contributor.authorDoğan, Sıtkı
dc.contributor.authorErdoğan, Turan
dc.date.accessioned2020-12-19T20:17:13Z
dc.date.available2020-12-19T20:17:13Z
dc.date.issued2015
dc.identifier.citationÇiçek, Y., Kocaman, S. A., Durakoğlugil, M. E., Çetin, M., Çanga, A., Bozok, Ş., Doğan, S., & Erdoğan, T. (2015). Relationship of fragmented QRS with prognostic markers and long-term major adverse cardiac events in patients undergoing coronary artery bypass graft surgery. Journal of cardiovascular medicine (Hagerstown, Md.), 16(2), 112–117. https://doi.org/10.2459/01.JCM.0000435615.40439.68en_US
dc.identifier.issn1558-2027
dc.identifier.urihttps://doi.org/10.2459/01.JCM.0000435615.40439.68
dc.identifier.urihttps://hdl.handle.net/11436/4357
dc.descriptionPubMed: 25545656en_US
dc.description.abstractBackground: Fragmented QRS (fQRS) complex is associated with increased sudden cardiac death, recurrent cardiovascular events, morbidity and mortality. However, the prognostic role of fQRS has not been comprehensively studied in patients undergoing coronary artery bypass graft (CABG) surgery. In this study, we planned to investigate the relationship of fQRS with prognostic markers and long-term major adverse cardiovascular events (MACEs) following isolated CABG surgery. Methods: Two hundred and thirteen patients who underwent CABG surgery at our institution were enrolled consecutively. MACE was defined as cardiac death, recurrent myocardial infarction, decompensated heart failure and re-hospitalization. The patients were followed up for a mean duration of 26±10 months for MACE. Results: Patients with fQRS had a higher rate of Q wave on ECG (30 vs. 10%, P<0.001), more prolonged QRS time (99±11 vs. 88±13 ms, P<0.001), higher EUROSCORE (4.0±1.9 vs. 2.7±1.5, P<0.001) and lower left ventricular ejection fraction (44±12 vs. 56±12, P<0.001) in comparison with patients with non-fQRS. In addition, patients with fQRS had increased short-term and long-term MACE (17 vs. 4%, P=0.002; 23 vs. 6%, P<0.001, respectively) after discharge. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of fQRS for predicting MACE were 67, 71, 23, 94 and 70%, respectively. fQRS [odds ratio (OR) 3.110, 95% confidence interval (CI) 1.157-8.362, P=0.025] and prolonged QRS duration (>100 ms) (OR 3.898, 95% CI 1.463-10.39, P=0.007) were the only independent predictors of long-term MACE in multivariate logistic regression analysis. However, QRS duration had a better association with MACE than the presence of fQRS. Conclusion: fQRS and prolonged QRS duration may have an additional value in predicting cardiac status and long-term prognosis. Fragmentations on admission ECG and prolonged QRS duration may be useful for identifying patients with higher long-term risk who will need more intense treatment and close follow-up after CABG surgery. © 2015 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiovascular risken_US
dc.subjectcoronary artery bypass graft surgeryen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectfragmented QRSen_US
dc.subjectlong-termen_US
dc.subjectmajor adverse cardiovascular eventsen_US
dc.subjectpredictive valueen_US
dc.titleRelationship of fragmented QRS with prognostic markers and long-term major adverse cardiac events in patients undergoing coronary artery bypass graft surgeryen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorÇiçek, Yüksel
dc.contributor.institutionauthorKocaman, Sinan Altan
dc.contributor.institutionauthorDurakoğlugil, Murtaza Emre
dc.contributor.institutionauthorÇetin, Mustafa
dc.contributor.institutionauthorÇanga, Aytun
dc.contributor.institutionauthorBozok, Şahin
dc.contributor.institutionauthorDoğan, Sıtkı
dc.contributor.institutionauthorErdoğan, Turan
dc.identifier.doi10.2459/01.JCM.0000435615.40439.68
dc.identifier.volume16en_US
dc.identifier.issue2en_US
dc.identifier.startpage112en_US
dc.identifier.endpage117en_US
dc.relation.journalJournal of Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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