dc.contributor.author | Okutucu, Murat | |
dc.contributor.author | Fındık, Hüseyin | |
dc.contributor.author | Aslan, Mehmet Gökhan | |
dc.contributor.author | Arpa, Medeni | |
dc.date.accessioned | 2022-08-09T12:10:44Z | |
dc.date.available | 2022-08-09T12:10:44Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Okutucu, M., Fındık, H., Aslan, M. G., & Arpa, M. (2021). Increased serum concentration of netrin-1 after intravitreal bevacizumab injection: is it a compensatory mechanism to counteract drug side effects?. BMC ophthalmology, 21(1), 243. https://doi.org/10.1186/s12886-021-01989-1 | en_US |
dc.identifier.issn | 1471-2415 | |
dc.identifier.uri | https://doi.org/10.1186/s12886-021-01989-1 | |
dc.identifier.uri | https://hdl.handle.net/11436/6316 | |
dc.description.abstract | Background To evaluate alterations in the serum concentrations of vascular endothelial growth factor (VEGF) and netrin-1 after intravitreal bevacizumab (BCZ) injection for the treatment of diabetic macular edema (DME). Methods This prospective case-control study included a total of 50 participants assigned to one of three groups, including 10 individuals with DME and non-proliferative diabetic retinopathy (NPDR), 13 with DME, and proliferative diabetic retinopathy (PDR), and 27 healthy individuals as a control group. Serum VEGF and netrin-1 concentrations were measured by enzyme-linked immunosorbent assays (ELISAs) immediately before, as well as 1 week and 1 month after, intravitreal BCZ injection. Results The mean VEGF serum concentrations in the PDR and NPDR groups were 388.4 and 196.9 pg/mL at baseline, respectively. After 1 week, these concentrations changed to 193.41 and 150.23 pg/mL, respectively (P = 0.001 and P = 0.005, respectively); after 1 month, the concentrations were 97.89 and 76.46 pg/mL, respectively (P = 0.001 and P = 0.009, respectively). The mean netrin-1 serum concentrations in the PDR patients and NPDR groups were 318.2 and 252.7 pg/mL at baseline, respectively. After 1 week, these concentrations increased to 476.6 and 416.3 pg/mL, respectively (P = 0.033 and P = 0.005, respectively), and after 1 month, they were 676.6 and 747.5 pg/mL, respectively (P = 0.001 and P = 0.005, respectively). The correlation analysis revealed a significant inverse relationship between changes in serum VEGF and netrin-1 concentrations in both the PDR and NPDR groups (r = - 0.685, P = 0.029). Conclusions Intravitreal BCZ injections work systemically to significantly decrease serum VEGF levels, leading to a significant upregulation in the concentration of another angiogenic mediator, netrin-1. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Vascular endothelial growth factor | en_US |
dc.subject | Netrin-1 | en_US |
dc.subject | Bevacizumab | en_US |
dc.subject | Macular edema | en_US |
dc.subject | Diabetic retinopathy | en_US |
dc.title | Increased serum concentration of netrin-1 after intravitreal bevacizumab injection: is it a compensatory mechanism to counteract drug side effects? | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Okutucu, Murat | |
dc.contributor.institutionauthor | Fındık, Hüseyin | |
dc.contributor.institutionauthor | Aslan, Mehmet Gökhan | |
dc.contributor.institutionauthor | Arpa, Medeni | |
dc.identifier.doi | 10.1186/s12886-021-01989-1 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 243 | en_US |
dc.relation.journal | BMC Ophthalmology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |