The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion

Abstract

Background High serum uric acid (UA) levels and low high-density lipoprotein cholesterol (HDL- C) levels are accepted as risk factors for cardiovascular mortality. Hyperuricemia and low HDL-C levels were associated with an increased risk of cardiovascular mortality and the development of diabetes and hypertension. However, the association of UA with cardiovascular (CV) mortality,collateral index are undetermined in patients with chronic total occlusion (CTO).

Material and methods 124 patients who underwent coronary angiography with the diagnosis of stable or unstable angina pectoris and had chronic total occlusion were included in our study. Blood samples were collected from all patients before the angiography procedure. Coronary collateral circulation (CCC) was graded according to the Rentrop grading system of 0-3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high- grade CCC group. We divided our patients into two groups as low-grade CCC and high-grade CCC and examined these two groups in terms of uric acid / HDL ratios. Group 1: Rentrop classification grade 0-1 (mean age, 63,9 +/- 9,9), Group 2: Rentrop classification grade 2-3 (mean age, 62,1 +/- 9,4).

Results The baseline characteristics were similar in both groups. Uric acid/ High density lipoproteincholesterol ratios and uric acid levels were higher in group 1 with poor collateral circulation [group 1; 0,21 (0,07-0,39) vs. group 2; 0,16 (0,08-0,31), group 1; 8,2 (3,4-10,4) vs. group 2; 5,85 (3,5-7,7), p<0,001, p<0,001 respectively].

Conclusions We found that high Uric acid/ High-density lipoprotein-cholesterol ratios and high uric acid levels are associated with poor collateral circulation.