dc.contributor.author | Yaylı, Nurettin | |
dc.contributor.author | Kılıç, Gözde | |
dc.contributor.author | Çelik, Gözde | |
dc.contributor.author | Kahriman, Nuran | |
dc.contributor.author | Kanbolat, Şeyda | |
dc.contributor.author | Bozdeveci, Arif | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Aliyazıcıoğlu, Rezzan | |
dc.contributor.author | Sellitepe, Hasan Erdinç | |
dc.contributor.author | Doğan, İnce Selin | |
dc.contributor.author | Aydın, Ali | |
dc.date.accessioned | 2022-10-16T15:03:41Z | |
dc.date.available | 2022-10-16T15:03:41Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Yaylı, N., Kılıç, G., Kahriman, N., Kanbolat, Ş., Bozdeveci, A., Alpay Karaoğlu, Ş., Aliyazıcıoğlu, R., Erdinç Sellitepe, H., Selin Doğan, İ., Aydın, A., & Tatar, G. (2021). Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant,antimicrobial, enzyme inhibition, and cytotoxic activities. Turkish Journal of Chemistry, 45(3), 788-804. https://doi.org/10.3906/kim-2012-25 | en_US |
dc.identifier.citation | 10.3906/kim-2012-25 | en_US |
dc.identifier.issn | 1300-0527 | |
dc.identifier.uri | https://doi.org/10.3906/kim-2012-25 | |
dc.identifier.uri | https://hdl.handle.net/11436/6756 | |
dc.description.abstract | In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-beta-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, alpha-amylase, and alpha- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program's help. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Scientific Technical Research Council Turkey - TUBİTAK | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hydroxy benzoin/benzil | en_US |
dc.subject | Benzoin/benzi1-O-beta-D-glucoside | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Enzyme inhibition | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.title | Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Bozdeveci, Arif | |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.volume | 45 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 788 | en_US |
dc.identifier.endpage | 804 | en_US |
dc.relation.journal | Bioorganic Chemistry | en_US |
dc.relation.tubitak | 117R048 | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |