dc.contributor.author | Bıyıklıoğlu, Zekeriya | |
dc.contributor.author | Keleş, Turgut | |
dc.contributor.author | Şahin, Hüseyin | |
dc.date.accessioned | 2022-11-16T11:39:00Z | |
dc.date.available | 2022-11-16T11:39:00Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Biyiklioglu, Z., Keles, T. & Sahin, H. (2022). Synthesis and acetylcholinesterase enzyme inhibition properties of axially disubstituted silicon phthalocyanines and their quaternized derivatives. Journal of Organometallic Chemistry, 977, 122468. https://doi.org/10.1016/j.jorganchem.2022.122468 | en_US |
dc.identifier.issn | 0022-328X | |
dc.identifier.issn | 1872-8561 | |
dc.identifier.uri | https://doi.org/10.1016/j.jorganchem.2022.122468 | |
dc.identifier.uri | https://hdl.handle.net/11436/7056 | |
dc.description.abstract | In this paper, axial 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines ( PP-D-Si, PP-OH2-Si) and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were synthesized and characterized. The acetyl -cholinesterase inhibition values of 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines ( PP-D-Si, PP-OH2-Si) and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were measured by IC50 that reduces enzyme activity to 50% refers to the concentration of inhibitor. The synthesis compounds were classified as silicon and their quaternized derivatives and tagged as PP-D-Si, PP-OH2-Si, PP-D-SiQ and PP-OH2-SiQ. Except for the result of PP-D-SiQ was 1.586 & PLUSMN; 0.129 mu M, the results were expressed as mM ranged between 0.553 and 3.626 mM. (c) 2022 Published by Elsevier B.V. | en_US |
dc.description.sponsorship | Research Fund of Karadeniz Technical University 8762 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Silicon | en_US |
dc.subject | Phthalocyanine | en_US |
dc.subject | Enzyme inhibition | en_US |
dc.subject | Cholinesterase | en_US |
dc.title | Synthesis and acetylcholinesterase enzyme inhibition properties of axially disubstituted silicon phthalocyanines and their quaternized derivatives | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Keleş, Turgut | |
dc.identifier.doi | 10.1016/j.jorganchem.2022.122468 | en_US |
dc.identifier.volume | 977 | en_US |
dc.identifier.startpage | 122468 | en_US |
dc.relation.journal | Journal of Organometallic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |