dc.contributor.author | Barut, Burak | |
dc.contributor.author | Keleş, Turgut | |
dc.contributor.author | Bıyıklıoğlu, Zekeriya | |
dc.contributor.author | Yalçın, Can Özgür | |
dc.date.accessioned | 2022-12-20T08:17:03Z | |
dc.date.available | 2022-12-20T08:17:03Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Barut, B., Keles, T., Biyiklioglu, Z. & Yalcin, C.O. (2020). Peripheral or nonperipheral tetra-[4-(9H-carbazol-9-yl)phenoxy] substituted cobalt(II), manganese(III) phthalocyanines: Synthesis, acetylcholinesterase, butyrylcholinesterase, and α-glucosidase inhibitory effects and anticancer activities. Applied Organometallic Chemistry, 35(1), e6021. https://doi.org/10.1002/aoc.6021 | en_US |
dc.identifier.issn | 0268-2605 | |
dc.identifier.uri | https://doi.org/10.1002/aoc.6021 | |
dc.identifier.uri | https://hdl.handle.net/11436/7279 | |
dc.description.abstract | In this work, peripheral or nonperipheral tetra-[4-(9H-carbazol-9-yl)phenoxy] substituted cobalt(II), manganese (III) phthalocyanines were synthesized for the first time. Their acetylcholinesterase from Electrophorus electricus (AChE), butyrylcholinesterase equine serum (BuChE), and α-glucosidase Saccharomyces cerevisiae inhibition were investigated spectrophotometrically. Finally, in vitro cytotoxicities of the compounds were investigated on human neuroblastoma (SH-SY5Y) cell line using MTT cell viability assay. The compounds inhibited to enzymes in the range of 7.39 ± 0.25–35.29 ± 2.49 μM with IC50 values for AChE and 14.38 ± 0.66–58.02 ± 4.94 μM for BuChE as compared with galantamine, which used as a positive control. For α-glucosidase, all compounds had stronger inhibition action than acarbose according to the IC50 values. The IC50 values of N-Co and N-Mn were found to be 3.05 ± 0.10 and 15.82 ± 1.85 μM, respectively. The results of cytotoxicity showed that the IC50 values were above 100 μM showing the compounds had low cytotoxic action against SH-SY5Y cell line for 24 h. Overall, carbazole substituted nonperipheral compounds can be considered as a potential agent for the treatment of Alzheimer's diseases and diabetes mellitus. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alzheimer's diseases | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Enzyme inhibition | en_US |
dc.subject | Phthalocyanine | en_US |
dc.title | Peripheral or nonperipheral tetra-[4-(9H-carbazol-9-yl)phenoxy] substituted cobalt(II), manganese(III) phthalocyanines: Synthesis, acetylcholinesterase, butyrylcholinesterase, and α-glucosidase inhibitory effects and anticancer activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Keleş, Turgut | |
dc.identifier.doi | 10.1002/aoc.6021 | en_US |
dc.identifier.volume | 35 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | e6021 | en_US |
dc.relation.journal | Applied Organometallic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |