dc.contributor.author | Arpa, Medeni | |
dc.contributor.author | Şen, Bayram | |
dc.contributor.author | Beyazal, Münevver Serdaroğlu | |
dc.contributor.author | Erel, Özcan | |
dc.date.accessioned | 2023-01-07T16:01:35Z | |
dc.date.available | 2023-01-07T16:01:35Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Arpa, M., Şen, B., Beyazal, M. S., & Erel, Ö. (2021). Evaluation of Thiol-disulfide Homeostasis in Active Ankylosing Spondylitis Patients. Reumatologia clinica, 18(6), 343-348. https://doi.org/10.1016/j.reuma.2021.03.007 | en_US |
dc.identifier.issn | 1699-258X | |
dc.identifier.uri | https://doi.org/10.1016/j.reuma.2021.03.007 | |
dc.identifier.uri | https://hdl.handle.net/11436/7349 | |
dc.description.abstract | Introduction and objectives: The etiopathogenesis of ankylosing spondylitis (AS), which is a chronic, progressive, inflammatory, systemic disease, has not been fully elucidated yet. Thiol-disulfide homeostasis, a component of antioxidant defense, is thought to play a role in the etiology of inflammatory diseases. We aimed to evaluate the existence of oxidative stress in active AS patients with thiol-disulfide homeostasis. Materials and methods: Patients who were found to have high (n: 27) and very-high (n: 18) activity levels with ASDAS-ESR and 40 healthy controls participated in the study. Serum native-thiol (NT), total-thiol (TT), and disulfide levels were analyzed by an automated colorimetric method. Results: While TT and NT levels were significantly decreased in patients compared to the control group, the disulfide levels were increased. There was a significant negative correlation between ESR, and NT, TT in both groups and also between hsCRP and NT, TT in very-high active AS patients.TT and NT levels were significantly higher in the nonsteroidal anti-inflammatory drug (NSAID) users compared to those using biological agents. Conclusions: The deterioration of thiol-disulfide homeostasis in favor of disulfide; correlations between ESR, CRP, and NT, TT support the use of thiol-disulfide variables in determining the disease activity level. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Ediciones Doyma, S.L. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Arpa, Medeni | en_US |
dc.subject | Şen, Bayram | en_US |
dc.subject | Beyazal, Münevver Serdaroğlu | en_US |
dc.subject | Erel, Özcan | en_US |
dc.title | Evaluation of thiol-disulfide homeostasis in active ankylosing spondylitis patients | en_US |
dc.title.alternative | Evaluación de la homeostasis de tiol-disulfuro en pacientes con espondilitis anquilosante activa | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Arpa, Medeni | |
dc.contributor.institutionauthor | Şen, Bayram | |
dc.contributor.institutionauthor | Beyazal, Münevver Serdaroğlu | |
dc.identifier.doi | 10.1016/j.reuma.2021.03.007 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 343 | en_US |
dc.identifier.endpage | 348 | en_US |
dc.relation.journal | Reumatologia Clinica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |