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dc.contributor.authorGündoğdu, Hasan
dc.contributor.authorBedir, Recep
dc.contributor.authorEren, Hüseyin
dc.contributor.authorErok, Berrin
dc.date.accessioned2023-03-01T06:55:24Z
dc.date.available2023-03-01T06:55:24Z
dc.date.issued2022en_US
dc.identifier.citationGündoğdu, H., Bedir, R., Eren, H. & Erok, B. (2022). The role of diffusion-weighted imaging on 3 tesla magnetic resonance in the clinical staging and pathological grading of clear cell renal carcinoma. Experimental Biomedical Research, 5(1), 125-134. http://doi.org/10.30714/j-ebr.2022173857en_US
dc.identifier.issn2618-6454
dc.identifier.urihttp://doi.org/10.30714/j-ebr.2022173857
dc.identifier.urihttps://hdl.handle.net/11436/7729
dc.description.abstractAim: To evaluate the contribution of the apparent diffusion coefficient (ADC) to distinguish between the four clinical stages and pathological grading in patients with clear cell renal cell carcinoma (RCC) on 3T MRI. Methods: MRI of 93 patients with histopathological diagnosis of clear cell RCC were evaluated retrospectively. Clinical stage was evaluated according to American Joint Committee on Cancer and histopathological examination was evaluated according to the Fuhrman grading system. ADC values were compared for each clinical stage and pathological grade. Results: Clinical stages were I in 51 patients (54.8%), II in 14 patients (15%), III in 15 patients (16.1%), and IV in 13 patients (13.9%). The Fuhrman grade of the patients were I in 8 (8.6%) patients, II in 55 (59.1%) patients, III in 23 (24.7%) patients and IV in 7 (7.5%) patients. Clinical stage I and Fuhrman grade I had significantly higher ADC values than all groups (p<0.001). The sensitivity was 81% and the specificity was 80.4% when the optimum cut-off value of ADC was taken as 1.41×10−3 mm2 /s to differentiate between clinical stage I and other stages (II, III, and IV) (AUC:0.910; 95CI:0.855-0.964; p<0.001). The optimum cutoff value of ADC was taken as 1.67×10−3 mm2 /s to differentiate between Fuhrman grade I and other grades (II, III and IV), the sensitivity was 88.2% and the specificity was 100% (AUC: 0.927; 95CI: 0.872- 0.983; p<0.001). Conclusions: In patients with renal mass suggestive of clear cell RCC in imaging studies; The possibility of lymph node or distant metastatic lesion should be considered in patients with an ADC of the primary tumor site less than 1.41×10−3 mm2 /s, and the presence of distant metastasis in patients with an ADC less than 1.22×10−3 mm2 /s.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClear cell renal cell carcinomaen_US
dc.subjectApparent diffusion coefficientsen_US
dc.subjectClinical stageen_US
dc.subjectFuhrman graden_US
dc.subjectMRIen_US
dc.titleThe role of diffusion-weighted imaging on 3 tesla magnetic resonance in the clinical staging and pathological grading of clear cell renal carcinomaen_US
dc.typeconferenceObjecten_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorGündoğdu, Hasan
dc.contributor.institutionauthorBedir, Recep
dc.contributor.institutionauthorEren, Hüseyin
dc.identifier.doi10.30714/j-ebr.2022173857en_US
dc.identifier.volume5en_US
dc.identifier.issue1en_US
dc.identifier.startpage125en_US
dc.identifier.endpage134en_US
dc.relation.journalExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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