dc.contributor.author | Balık, Mehmet Sabri | |
dc.contributor.author | Çeliker, Fatma Beyazal | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Topçu, Atilla | |
dc.contributor.author | Şahin, Rıfat | |
dc.contributor.author | Balık, Gülşah | |
dc.date.accessioned | 2023-03-20T06:18:43Z | |
dc.date.available | 2023-03-20T06:18:43Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Balik, M. S., Celiker, F. B., Tumkaya, L., Mercantepe, T., Topcu, A., Sahin, R., & Balik, G. (2022). Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle. Northern clinics of Istanbul, 9(6), 632–637. https://doi.org/10.14744/nci.2021.45143 | en_US |
dc.identifier.issn | 2148-4902 | |
dc.identifier.issn | 2536-4553 | |
dc.identifier.uri | https://doi.org/10.14744/nci.2021.45143 | |
dc.identifier.uri | https://hdl.handle.net/11436/7931 | |
dc.description.abstract | OBJECTIVE: We investigated the effects on skeletal muscle of gadolinium based linear and macrocyclic radiocontrast agents
applied at experimental intervals using histopathological methods.
METHODS: Thirty-two male Sprague–Dawley rats were included in the study for histopathological analysis. No procedure
was performed on the healthy control group. The sham group received 0.1 ml/kg intravenous (IV) saline solution through
the tail vein 4 times weekly for 5 weeks. The gadodiamide group received total 2 mmol/kg IV gadodiamide through the tail
vein 4 times weekly for 5 weeks. The gadoteric-acid group received 2 mmol/kg IV gadoteric acid through the tail vein 4 times
weekly for 5 weeks.
RESULTS: We determined no marked apoptotic myofibrils associated withcaspase-3 expression in these two groups. Furthermore, no calcineurin expression was observed in myofibrils in the two groups. However, quantitative analyses revealed
a decrease in muscle-fiber area in the gadodiamide and gadoteric-acid groups compared to the control group (Respectively;
p=0.001 and p=0.017).
CONCLUSION: In our experimental study, linear and macrocyclic GBCAs applied at repeated doses played no role in myofibril damage induced by caspase-3 and calcineurin – nuclear factor of activated T-cells in skeletal muscle tissue. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Calcineurin | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Gadodiamide | en_US |
dc.subject | Gadoteric acid | en_US |
dc.subject | Skeletal muscle | en_US |
dc.title | Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Balık, Mehmet Sabri | |
dc.contributor.institutionauthor | Çeliker, Fatma Beyazal | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Topçu, Atilla | |
dc.contributor.institutionauthor | Şahin, Rıfat | |
dc.contributor.institutionauthor | Balık, Gülşah | |
dc.identifier.doi | 10.14744/nci.2021.45143 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 632 | en_US |
dc.identifier.endpage | 637 | en_US |
dc.relation.journal | Northern Clinics of Istanbul | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |