Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats
Citation
Bahcecı, I., Tumkaya, L., Mercantepe, T., Yılmaz, H., Ibık, Y. E., Duran, O. F., & Arslan, N. (2023). Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats. European review for medical and pharmacological sciences, 27(3), 1140–1146. https://doi.org/10.26355/eurrev_202302_31220Abstract
OBJECTIVE: Carbon tetrachloride (CCl4
) is a non-polar molecule used in industry in grain curing, insect-killing and especially in
the production of chlorofluorocarbons. It is estimated that an average of 70,000 industry workers
in Europe are exposed to this toxic compound.
MATERIALS AND METHODS: Twenty-four
male Sprague-Dawley rats were randomly allocated into four groups: control group (saline only, Group I), infliximab (INF) group (Group II), CCl4
group (Group III) and CCl4+INF group (Group IV).
RESULTS: While there was an increase in the
numerical density of CD3, CD68, and CD200R
positive T lymphocytes and macrophages in
the CCl4
administration group (p=0.000), this
was not the case in the CCl4+INF administration
group (p=0.000).
CONCLUSIONS: TNF-α inhibitors have a protective effect against CCl4-induced spleen toxicity/inflammation as seen by the reduction in
CD3, CD68, CD200R positive T lymphocytes and
macrophages.
