dc.contributor.author | Bahçeci, İlkay | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Yılmaz, H. | |
dc.contributor.author | İbik, Y.E. | |
dc.contributor.author | Duran, Ömer Faruk | |
dc.contributor.author | Arslan, Nurgül | |
dc.date.accessioned | 2023-08-11T10:17:29Z | |
dc.date.available | 2023-08-11T10:17:29Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Bahcecı, I., Tumkaya, L., Mercantepe, T., Yılmaz, H., Ibık, Y. E., Duran, O. F., & Arslan, N. (2023). Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats. European review for medical and pharmacological sciences, 27(3), 1140–1146. https://doi.org/10.26355/eurrev_202302_31220 | en_US |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://doi.org/10.26355/eurrev_202302_31220 | |
dc.identifier.uri | https://hdl.handle.net/11436/7968 | |
dc.description.abstract | OBJECTIVE: Carbon tetrachloride (CCl4
) is a non-polar molecule used in industry in grain curing, insect-killing and especially in
the production of chlorofluorocarbons. It is estimated that an average of 70,000 industry workers
in Europe are exposed to this toxic compound.
MATERIALS AND METHODS: Twenty-four
male Sprague-Dawley rats were randomly allocated into four groups: control group (saline only, Group I), infliximab (INF) group (Group II), CCl4
group (Group III) and CCl4+INF group (Group IV).
RESULTS: While there was an increase in the
numerical density of CD3, CD68, and CD200R
positive T lymphocytes and macrophages in
the CCl4
administration group (p=0.000), this
was not the case in the CCl4+INF administration
group (p=0.000).
CONCLUSIONS: TNF-α inhibitors have a protective effect against CCl4-induced spleen toxicity/inflammation as seen by the reduction in
CD3, CD68, CD200R positive T lymphocytes and
macrophages. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verduci Publisher | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carbon tetrachloride | en_US |
dc.subject | CD3 | en_US |
dc.subject | CD68 | en_US |
dc.subject | CD200R | en_US |
dc.subject | Spleen | en_US |
dc.title | Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Bahçeci, İlkay | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Yılmaz, H. | |
dc.contributor.institutionauthor | İbik, Y.E | |
dc.contributor.institutionauthor | Duran, Ömer Faruk | |
dc.contributor.institutionauthor | Arslan, Nurgül | |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1140 | en_US |
dc.identifier.endpage | 1146 | en_US |
dc.relation.journal | European Review for Medical and Pharmacological Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |