dc.contributor.author | Ergene, Şaban | |
dc.contributor.author | Hemşinli, Doğuş | |
dc.contributor.author | Karakişi, Sedat Ozan | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Yılmaz, Adnan | |
dc.date.accessioned | 2023-08-14T07:04:24Z | |
dc.date.available | 2023-08-14T07:04:24Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Ergene, S., Hemsinli, D., Karakisi, S. O., Tumkaya, L., Mercantepe, T., & Yılmaz, A. (2023). Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping. European review for medical and pharmacological sciences, 27(8), 3396–3405. https://doi.org/10.26355/eurrev_202304_32110 | en_US |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://doi.org/10.26355/eurrev_202304_32110 | |
dc.identifier.uri | https://hdl.handle.net/11436/7977 | |
dc.description.abstract | OBJECTIVE: Acute kidney inju-ry (AKI) is one of the main causes of mortality in patients undergoing emergency surgery due to an abdominal aortic aneurysm. This study aimed to determine the potential nephroprotec-tive characteristics of dexmedetomidine (DMD) for the establishment of a standard therapeutic method for AKI.MATERIALS AND METHODS: Thirty Spra-que Dawley rats were allocated to 4 groups: con-trol, sham, ischemia-reperfusion, and ischemia/ reperfusion (I/R)+dexmedatomidine.RESULTS: Necrotic tubules, degenerative Bowman's capsule and vascular congestion were observed in the I/R group. In addition, there was an increase in tissue malondialdehyde (MDA), interleukin (IL)-1 and IL-6 levels in tubu-lar epithelial cells. In contrast, we observed de-creased tubular necrosis, IL-1, IL-6 and MDA lev-els in the DMD treatment group.CONCLUSIONS: DMD has a nephroprotective effect against acute kidney injury resulting from I/R, which is related to aortic occlusion used in the treatment of ruptured abdominal aortic an-eurysms. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verduci Publisher | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute kidney injury | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Ruptured abdominal aortic aneurysms | en_US |
dc.title | Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Ergene, Şaban | |
dc.contributor.institutionauthor | Hemşinli, Doğuş | |
dc.contributor.institutionauthor | Karakişi, Sedat Ozan | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.identifier.doi | 10.26355/eurrev_202304_32110 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 3396 | en_US |
dc.identifier.endpage | 3405 | en_US |
dc.relation.journal | European review for medical and pharmacological sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |