dc.contributor.author | Keklikkıran, Çağlayan | |
dc.contributor.author | Stepanova, Maria | |
dc.contributor.author | Younossi, Zobair | |
dc.contributor.author | Yılmaz, Yusuf | |
dc.date.accessioned | 2023-08-22T06:32:20Z | |
dc.date.available | 2023-08-22T06:32:20Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Keklikkiran, C., Stepanova, M., Younossi, Z., & Yilmaz, Y. (2023). Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Non-alcoholic Fatty Liver Disease? Hints from a Registry-based Study. Digestive diseases (Basel, Switzerland), 10.1159/000531981. Advance online publication. https://doi.org/10.1159/000531981 | en_US |
dc.identifier.issn | 0257-2753 | |
dc.identifier.issn | 1421-9875 | |
dc.identifier.uri | https://doi.org/10.1159/000531981 | |
dc.identifier.uri | https://hdl.handle.net/11436/8094 | |
dc.description.abstract | Introduction: While poor oral hygiene has been previously associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an easy-to-assess indicator of oral health habits, would be associated with liver stiffness measurement (LSM) by transient elastography (TE) in patients with an established diagnosis of NAFLD. Methods: In this registry-based study, LSM was measured in 1156 patients with NAFLD and analyzed in relation to the self-reported daily frequency of toothbrushing. LSM values & GE;12 kPa were considered as indicative of cirrhosis. Results: A trend towards a stepwise decrease (cross-sectional p = 0.13) in LSM was found in patients who reported having their teeth brushed more frequently: less than once a day (10.6 & PLUSMN; 8.6 kPa; 13% of the study sample), once a day (9.95 & PLUSMN; 8.40 kPa; 40%), twice a day (9.21 & PLUSMN; 7.63 kPa; 43%), and after every meal (8.91 & PLUSMN; 5.30 kPa; 4%). Patients who brushed their teeth less than once a day had a significantly higher prevalence of LSM values & GE;12 kPa (p < 0.05). In multivariable logistic regression analysis, the association of LSM values & GE; 12 kPa with toothbrushing habits remained statistically significant for less than once a day (odds ratio = 1.69, 95% confidence interval = 1.07-2.66, p = 0.02) with reference to twice a day or after every meal. Conclusion: Among patients with NAFLD, there is an independent association between brushing teeth less than once a day and TE-established cirrhosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Fibrosis | en_US |
dc.title | Can frequent toothbrushing reduce the risk of cirrhosis among patients with non-alcoholic fatty liver disease? Hints from a registry-based study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Keklikkıran, Çağlayan | |
dc.contributor.institutionauthor | Yılmaz, Yusuf | |
dc.identifier.doi | 10.1159/000531981 | en_US |
dc.relation.journal | Digestive Diseases | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |