dc.contributor.author | Zhang, Huai | |
dc.contributor.author | Rios, Rafael S. | |
dc.contributor.author | Boursier, Jerome | |
dc.contributor.author | Anty, Rodolphe | |
dc.contributor.author | Chan, Wah-Kheong | |
dc.contributor.author | George, Jacob | |
dc.contributor.author | Yılmaz, Yusuf | |
dc.contributor.author | Wong, Vincent Wai-Sun | |
dc.contributor.author | Fan, Jiangao | |
dc.contributor.author | Dufour, Jean-Francois | |
dc.contributor.author | Papatheodoridis, George | |
dc.contributor.author | Chen, Li | |
dc.contributor.author | Schattenberg, Joern M | |
dc.contributor.author | Shi, Junping | |
dc.contributor.author | Xu, Liang | |
dc.contributor.author | Wong, Grace Lai-Hung | |
dc.contributor.author | Lange, Naomi F. | |
dc.contributor.author | Papatheodoridi, Margarita | |
dc.contributor.author | Mi, Yuqiang | |
dc.contributor.author | Zhou, Yujie | |
dc.contributor.author | Byrne, Christopher D. | |
dc.contributor.author | Targher, Giovanni | |
dc.contributor.author | Feng, Gong | |
dc.contributor.author | Zheng, Minghua | |
dc.date.accessioned | 2023-09-08T07:09:29Z | |
dc.date.available | 2023-09-08T07:09:29Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Zhang, H., Rios, R. S., Boursier, J., Anty, R., Chan, W. K., George, J., Yilmaz, Y., Wong, V. W., Fan, J., Dufour, J. F., Papatheodoridis, G., Chen, L., Schattenberg, J. M., Shi, J., Xu, L., Wong, G. L., Lange, N. F., Papatheodoridi, M., Mi, Y., Zhou, Y., … Zheng, M. (2023). Hepatocyte apoptosis fragment product cytokeratin-18 M30 level and non-alcoholic steatohepatitis risk diagnosis: an international registry study. Chinese medical journal, 136(3), 341–350. https://doi.org/10.1097/CM9.0000000000002603 | en_US |
dc.identifier.issn | 0366-6999 | |
dc.identifier.issn | 2542-5641 | |
dc.identifier.uri | https://doi.org/10.1097/CM9.0000000000002603 | |
dc.identifier.uri | https://hdl.handle.net/11436/8281 | |
dc.description.abstract | Background:Liver biopsy for the diagnosis of non-alcoholic steatohepatitis (NASH) is limited by its inherent invasiveness and possible sampling errors. Some studies have shown that cytokeratin-18 (CK-18) concentrations may be useful in diagnosing NASH, but results across studies have been inconsistent. We aimed to identify the utility of CK-18 M30 concentrations as an alternative to liver biopsy for non-invasive identification of NASH.Methods:Individual data were collected from 14 registry centers on patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD), and in all patients, circulating CK-18 M30 levels were measured. Individuals with a NAFLD activity score (NAS) >= 5 with a score of >= 1 for each of steatosis, ballooning, and lobular inflammation were diagnosed as having definite NASH; individuals with a NAS <= 2 and no fibrosis were diagnosed as having non-alcoholic fatty liver (NAFL).Results:A total of 2571 participants were screened, and 1008 (153 with NAFL and 855 with NASH) were finally enrolled. Median CK-18 M30 levels were higher in patients with NASH than in those with NAFL (mean difference 177 U/L; standardized mean difference [SMD]: 0.87 [0.69-1.04]). There was an interaction between CK-18 M30 levels and serum alanine aminotransferase, body mass index (BMI), and hypertension (P < 0.001, P = 0.026 and P = 0.049, respectively). CK-18 M30 levels were positively associated with histological NAS in most centers. The area under the receiver operating characteristics (AUROC) for NASH was 0.750 (95% confidence intervals: 0.714-0.787), and CK-18 M30 at Youden's index maximum was 275.7 U/L. Both sensitivity (55% [52%-59%]) and positive predictive value (59%) were not ideal.Conclusion:This large multicenter registry study shows that CK-18 M30 measurement in isolation is of limited value for non-invasively diagnosing NASH. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Cytokeratin-18 | en_US |
dc.subject | Liver histology | en_US |
dc.subject | Non-alcoholic steatohepatitis | en_US |
dc.subject | Non-alcoholic fatty liver disease | en_US |
dc.title | Hepatocyte apoptosis fragment product cytokeratin-18 M30 level and non-alcoholic steatohepatitis risk diagnosis: an international registry study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Yılmaz, Yusuf | |
dc.identifier.doi | 10.1097/CM9.0000000000002603 | en_US |
dc.identifier.volume | 136 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 341 | en_US |
dc.identifier.endpage | 350 | en_US |
dc.relation.journal | Chinese Medical Journal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |