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Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
(Springer, 2022)
Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing ...
Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab
(Taylor & Francis Ltd., 2022)
Methotrexate (MTX) has been in use for the treatment of rheumatoid arthritis (RA), psoriasis, and cancer since 1948. Its toxic side effects on tissues and organs have been well documented but splenotoxicity has not been ...
The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation
(Verduci Editore, 2022)
OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ...
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
(Taylor & Francis Ltd., 2022)
Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ...
The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity
(Taylo & Francis Ltd., 2021)
Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ...
Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59
(Taylor & Francis Ltd, 2017)
Purpose: To investigate the effect on male rat kidney and bladder tissues of exposure to 900-megahertz (MHz) electromagnetic field (EMF) applied on postnatal days 22-59, inclusive. Materials and methods: Twenty-four male ...
Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity
(Wroclaw Medical Univ, 2018)
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ...
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
(Springer, 2018)
Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ...
Effects of gadolinium-based contrast agents on submandibular gland tissue in rats
(Springer, 2018)
The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on ...
Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats
(Spandidos Publ Ltd, 2018)
Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. the present study was ...