Kurum Yazarı "Baltaş, Nimet" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Bioevaluation of synthetic pyridones as dual inhibitors of alpha-amylase and alpha-glucosidase enzymes and potential antioxidants
Saleem, Faiza; Khan, Khalid Mohammed; Ullah, Nisar; Özil, Musa; Baltaş, Nimet; Hameed, Shehryar; Salar, Uzma; Wadood, Abdul; Rehman, Ashfaq Ur; Kumar, Mukesh; Taha, Muhammad; Haider, Syed Moazzam (Wiley, 2022)Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for alpha-amylase and alpha-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized ... -
Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol
Uydu, Hüseyin Avni; Bostan, Mehmet; Atak, Mehtap; Yılmaz, Adnan; Demir, Adem; Akcan, Buket; Sümer, Fatih; Baltaş, Nimet; Karadağ, Zakir; Uğurlu, Yavuz; Örem, Asım (Springer, 2014)Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. We ... -
Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, alpha-amylase, and antioxidant activities
Hameed, Shehryar; Khan, Khalid Mohammed; Salar, Uzma; Özil, Musa; Baltaş, Nimet; Saleem, Faiza; Qureshi, Urooj; Taha, Muhammad; Ul-Haq, Zaheer (Elsevier, 2022)A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS ... -
Indenoquinoxaline-phenylacrylohydrazide hybrids as promising drug candidates for the treatment of type 2 diabetes: In vitro and in silico evaluation of enzyme inhibition and antioxidant activity
Hameed, Shehryar; Saleem, Faiza; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Khan, Khalid Mohammed (Elsevier, 2024)Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and ... -
Indole-pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus
Solangi, Mehwish; Khan, Khalid Mohammed; Ji, Xingyue; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Khan, Alamgir; Ul-Haq, Zaheer; Meghwar, Herchand; Taha, Muhammad (2023)Background: Diabetes mellitus is a significant health disorder; therefore, researchers should focus on discovering new drug candidates. Methods: A series of indole-pyridine carbonitrile derivatives, 1-34, was synthesized ... -
Inhibition properties of propolis extracts to some clinically important enzymes
Baltaş, Nimet; Yıldız, Oktay; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)The present study was conducted to envisage inhibition effects of propolis on the crucial enzymes, urease, xanthine oxidase (XO) and acetylcholinesterase (AChE). Some of the antioxidant properties of the propolis samples ... -
Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors
Saleem, Faiza; Shamim, Fariha; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Solangi, Mehwish; Khan, Khalid Mohammed (2023)Background: Researchers seeking new drug candidates to treat diabetes mellitus have been exploring bioactive molecules found in nature, particularly tetrahydropyridines (THPs). Methods: A library of THPs (1–31) were ... -
Partial purification and characterization of lipase from Geobacillus stearothermophilus AH22
Ekinci, Arife Pınar; Dinçer, Barbaros; Baltaş, Nimet; Adıgüzel, Ahmet (Taylor & Francis Ltd, 2016)The lipase was partially purified by ion exchange chromatography and gel filtration column chromatography, and was characterized from Geobacillus stearothermophilus AH22 strain. the lipase was purified 18.3-folds with 19.7% ... -
Regioselective syntheses of 2-oxopyridine carbonitrile derivatives and evaluation for antihyperglycemic and antioxidant potential
Saleem, Faiza; Haider, Maham; Khan, Khalid Mohammed; Özil, Musa; Baltaş, Nimet; Ul-Haq, Zaheer; Qureshi, Urooj; Salar, Uzma; Taha, Muhammad; Hameed, Shehryar; Ullah, Nisar (Elsevier, 2023)A library of 2-oxopyridine carbonitriles 1-34 was synthesized by regioselective nucleophilic substitution reactions. In the first step, a one-pot multicomponent reaction yield pyridone intermediates. The resulting pyridone ... -
A simple and efficient synthesis of benzimidazoles containing piperazine or morpholine skeleton at C-6 position as glucosidase inhibitors with antioxidant activity
Özil, Musa; Parlak, Cansu; Baltaş, Nimet (Academic Press Inc Elsevier Science, 2018)A novel 2-(aryl)-6-morpholin-4-yl(or 4-methylpiperazin-1-yl)-1H-benzimidazole derivatives were designed and expeditiously synthesized starting from 5-morpholin-4-yl(or 4-methylpiperazin-1-yl)-2-nitroaniline with various ... -
Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings
Menteşe, Emre; Yılmaz, Fatih; Baltaş, Nimet; Bekircan, Olcay; Kahveci, Bahittin (Taylor & Francis Ltd, 2015)Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. the structures of the synthesized compounds (2-6) were ... -
Synthesis and kinetics studies of N '-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazide derivatives as potent antidiabetic agents
Menteşe, Emre; Baltaş, Nimet; Bekircan, Olcay (Wiley-V C H Verlag Gmbh, 2019)A novel series of N '-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazides were synthesized and studied for their alpha-glucosidase inhibition activity. Most of the ... -
Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease
Akyüz, Gülay; Menteşe, Emre; Emirik, Mustafa; Baltaş, Nimet (Academic Press Inc Elsevier Science, 2018)A new series of 2,3-disubstituted quinazolin-4(3H)-one compounds including oxadiazole and furan rings was synthesized. Their inhibitory activities on urease were assessed in vitro. All newly synthesized compounds exhibited ... -
Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors
Menteşe, Emre; Akyüz, Gülay; Yılmaz, Fatih; Baltaş, Nimet; Emirik, Mustafa (Wiley-V C H Verlag Gmbh, 2018)A new series of quinazolinone hybrid molecules containing coumarin, furan, 1,2,4-triazole and 1,2,4-thiadiazole rings was designed, synthesized, and screened for their urease inhibition activities. All newly synthesized ... -
Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives
Menteşe, Emre; Baltaş, Nimet; Emirik, Mustafa (Academic Press Inc Elsevier Science, 2020)In this study, a new series of 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives has been synthesized and screened for their alpha-glucosidase inhibitory potential. All molecules showed a considerable ... -
Synthesis, biological evaluation and in silico studies of new pyrazoline derivatives bearing benzo[d]thiazol-2(3H)-one moiety as potential urease inhibitors
Tok, Fatih; Baltaş, Nimet; Tatar, Gizem; Koçyiğiy Kaymakçıoğlu, Bedia (Wiley, 2022)Novel pyrazoline derivatives containing benzo[d]thiazol-2(3H)-one moiety were synthesized and screened for their inhibitory properties against urease, a clinically important metabolic enzyme. In vitro enzyme inhibition ... -
Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities
Menteşe, Emre; Akyüz, Gülay; Emirik, Mustafa; Baltaş, Nimet (Academic Press Inc Elsevier Science, 2019)A new series of quinazolinone derivatives containing triazole, thiadiazole, thiosemicarbazide functionalities was synthesized and then screened for their in vitro urease inhibition properties. Most of the compounds showed ...