Kurum Yazarı "Saydam, Faruk" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis
Hatipoğlu, Ömer; Saydam, Faruk (Elsevier, 2020)Objectives: Beta-defensin 1, encoded by the DEFB1 gene, is an important molecule that confers protection from dental caries. Numerous studies have been conducted on the rs11362 polymorphism in the DEFB1 gene. We evaluated ... -
Association between Taql polymorphism of vitamin D receptor gene and vertical growth of the mandible: A cross-sectional study
Objective: To determine whether the gonial angle on digital panoramic radiographs is associated with vitamin D receptor (VDR) Taql polymorphism. Methods: Genomic DNA samples were collected from the buccal mucosa of patients ... -
Association of paraoxonase 1 (PON1) gene polymorphisms and concentration with essential hypertension
Coşan, Didem Turgut; Çolak, Emine; Saydam, Faruk; Yazıcı, Hüseyin uğur; Değirmenci, İrfan; Birdane, Alparslan; Çolak, Ertuğrul; Güneş, Hasan Veysi (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as ... -
Common variants rs3815188 and rs1043994 on notch3 gene confer susceptibility to lung cancer: A hospital-based case-control study
Yağcı, Emine; Değirmenci, İrfan; Özbayer, Cansu; Ak, Güntulu; Saydam, Faruk; Metintaş, Muzaffer (Begell House Inc, 2019)The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related ... -
The CYP2C19*2 and CYP2C19*17 polymorphisms play a vital role in clopidogrel responsiveness after percutaneous coronary intervention: A pharmacogenomics study
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Ulus, Taner; Özbayer, Cansu; Çolak, Ertuğrul; Ata, Necmi; Güneş, Hasan Veysi (Wiley, 2017)Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients undergoing ... -
Effect of white tea consumption on serum leptin, TNF-alpha and UCP1 gene expression in ovariectomized rats
Saral, Sinan; Saydam, Faruk; Dokumacıoğlu, Eda; Atak, Mehtap; Tümkaya, Levent; Uydu, Hüseyin Avni (John Libbey Eurotext Ltd., 2021)Background: Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. ... -
The effects of carvacrol on transient receptor potential (TRP) channels in an animal model of parkinson's disease
Akan, Tülay; Aydın, Yasemin; Korkmaz, Tansel; Ulupınar, Emel; Saydam, Faruk (Springer, 2023)In this study, we aimed to investigate the effects of carvacrol (CA), a widely used phytochemical having anti-oxidant and neuroprotective effects, on transient receptor potential (TRP) channels in an animal model of ... -
The effects of monosodium glutamate and tannic acid on adult rats
Çalış, İbrahim Uğur; Coşan, Didem Turgut; Saydam, Faruk; Kolaç, Umut Kerem; Soyocak, Ahu; Kurt, Hülyam; Güneş, Hasan Veysi; Şahintürk, Varol; Mutlu, Fezan Şahin; Köroğlu, Zeynep Özdemir; Değirmenci, İrfan (Kowsar Publ, 2016)Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of MSG has been shown to increase oxidative stress in different organ systems and ... -
Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis
Hatipoğlu, Ömer; Saydam, Faruk (Polish Dental Soc, 2019)Background. Carbonic anhydrase VI (CA VI) is considered to greatly participate in the buffering of saliva, ion transport, the regulation of pH, secretory processes, and saliva production. Various studies have been conducted ... -
Is the 1254T > C polymorphism in the DMT1 gene associated with Parkinson's disease?
Saadat, Selva Moheb; Değirmenci, İrfan; Özkan, Serhat; Saydam, Faruk; Köroğlu, Zeynep Özdemir; Çolak, Ertuğrul; Güneş, Hasan Veysi (Elsevier Ireland Ltd, 2015)Parkinson's disease (PD) is a late-onset neurodegenerative disorder with both familial and sporadic presentation. the main pathological characteristic of PD is the death of dopaminergic neurons in the substantia nigra (SN) ... -
Tannic acid exhibits anti-inflammatory effects on formalin-induced paw edema model of inflammation in rats
Soyocak, Ahu; Kurt, Hülyam; Coşan, Didem Turgut; Saydam, Faruk; Çalış, İbrahim Uğur; Kolaç, Umut Kerem; Koroğlu, Zeynep Özdemir; Değirmenci, İrfan; Mutlu, Fezan; Güneş, Hasan Veysi (Sage Publications Ltd, 2019)The aim of the study was to determine the relationship between anti-inflammatory effects of the natural polyphenolic compound tannic acid (CAS number: 1401-55-4) and myeloperoxidase (MPO) enzyme activity in paw edema model. ... -
Targeting the anaphase-promoting complex/cyclosome (APC/C) enhanced antiproliferative and apoptotic response in bladder cancer
Nalkıran, Hatice Sevim; Yıldız, Dilara Akcora; Saydam, Faruk; Güzel, Ali İrfan; Nalkıran, İhsan (Elsevier, 2023)Improving the chemotherapy sensitivity of bladder cancer is a current clinical challenge. It is critical to seek out effective combination therapies that include low doses of cisplatin due to its dose-limiting toxicity. ... -
Variants in taste genes on caries risk and caries activity status
Telatar, Gül Yıldız; Saydam, Faruk; Güzel, Ali İrfan; Telatar, Barış Can (Springer Japan Kk, 2020)The aim of this study was to evaluate the role of taste-related gene polymorphisms (CA6,TAS1R1,TAS1R3, TLR2,andTLR4)on dental caries and caries activity in adults. Individuals aged 25-44 years included in the study were ...