dc.contributor.author | Demir, Elif Ayazoğlu | |
dc.contributor.author | Menteşe, Ahmet | |
dc.contributor.author | Küçük, Hatice | |
dc.contributor.author | Alemdar, Nihal Türkmen | |
dc.contributor.author | Demir, Selim | |
dc.contributor.author | Aliyazıcıoğlu, Yüksel | |
dc.date.accessioned | 2024-02-12T11:33:26Z | |
dc.date.available | 2024-02-12T11:33:26Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Demir, E.A., Menteşe, A., Küçük, H., Alemdar, N.T., Demir, S. & Aliyazıcıoğlu, Y. (2023). N-Acetylcysteine Ameliorates 5-Fluorouracil-Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences, 13(4), 776-781. https://doi.org/10.33808/clinexphealthsci.1199615 | en_US |
dc.identifier.issn | 2459-1459 | |
dc.identifier.uri | https://doi.org/10.33808/clinexphealthsci.1199615 | |
dc.identifier.uri | https://hdl.handle.net/11436/8785 | |
dc.description.abstract | Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time.Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically.Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p<.005). Treatments with NAC significantly restored these damages dose-dependently (p<.005). Moreover, these biochemical findings were confirmed by histological examination.Conclusion: NAC can be considered as a potential therapeutic molecule against 5-FU-induced reproductive toxicity, as it can abolish the ovarian toxicity caused by 5-FU by reducing oxidative stress, inflammation and apoptosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Marmara Üniversitesi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 5-Fluorouracil | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Inflammation | en_US |
dc.subject | N-acetylcysteine | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Ovotoxicity | en_US |
dc.title | N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü | en_US |
dc.contributor.institutionauthor | Alemdar, Nihal Türkmen | |
dc.identifier.doi | 10.33808/clinexphealthsci.1199615 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 776 | en_US |
dc.identifier.endpage | 781 | en_US |
dc.relation.journal | Clinical and Experimental Health Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |