dc.contributor.author | Çiftel, Serpil | |
dc.contributor.author | Mercantepe, Filiz | |
dc.date.accessioned | 2024-02-13T07:54:12Z | |
dc.date.available | 2024-02-13T07:54:12Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Ciftel, S., & Mercantepe, F. (2023). Relationship Between Overnight Dexamethasone Suppression Test and Aging. Cureus, 15(11), e48383. https://doi.org/10.7759/cureus.48383 | en_US |
dc.identifier.issn | 2168-8184 | |
dc.identifier.uri | https://doi.org/10.7759/cureus.48383 | |
dc.identifier.uri | https://hdl.handle.net/11436/8794 | |
dc.description.abstract | Background This study aims to investigate the relationship between suppressed cortisol levels measured after the 1-mg dexamethasone suppression test (DST) and age based on the hypothesis that aging can alter the activity of the hypothalamic-pituitary-adrenal (HPA) axis.Methodology Data obtained by the retrospective evaluation of suppressed 1-mg overnight DST results of adults aged >= 18 years with adrenal incidentaloma or suspected endogenous hypercortisolemia between December 2021 and March 2023 were subjected to age-dependent correlation analysis. Individuals aged between 18 and 90 years (n = 1111) were classified into the following four groups: <30 years, 30-49 years, 50-69 years, and >70 years. DST results were compared according to age groups.Results Median post-DST cortisol was 18.49 nmol/L, with a level of 17.9 nmol/L in females and 20.7 nmol/L in males. The overall rate of DST suppression was 62.7%, with a rate of 63.8% in females and 59.7% in males. On pairwise comparisons of all age groups, there was a difference in post-DST cortisol levels (p = 0.000). Our statistical analysis revealed a strong positive correlation between age and cortisol levels after DST.Conclusions The negative feedback mechanism for cortisol may be altered in older patients. Therefore, the 1-mg DST may yield a higher rate of false positives in the elderly. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Cureus Inc. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Pituitary incidentaloma | en_US |
dc.subject | Adrenal gland incidentaloma | en_US |
dc.subject | Elderly population | en_US |
dc.subject | Dexamethasone suppression test | en_US |
dc.subject | Aging | en_US |
dc.subject | Adrenal glands | en_US |
dc.title | Relationship between overnight dexamethasone suppression test and aging | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Mercantepe, Filiz | |
dc.identifier.doi | 10.7759/cureus.48383 | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | e48383 | en_US |
dc.relation.journal | Cureus Journal of Medical Science | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |