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dc.contributor.authorBarut, Burak
dc.contributor.authorSeyhan, Gökçe
dc.contributor.authorKeleş, Turgut
dc.contributor.authorKulein, Barış
dc.contributor.authorBıyıklıoğlu, Zekeriya
dc.date.accessioned2024-03-28T08:21:13Z
dc.date.available2024-03-28T08:21:13Z
dc.date.issued2024en_US
dc.identifier.citationBarut, B., Seyhan, G., Keleş, T., Kulein, B. & Bıyıklıoğlu, Z. (2024). Nonperipherally and peripherally substituted water-soluble magnesium (II) phthalocyanines and their DNA binding, nuclease activities. Applied Organometallic Chemistry. https://doi.org/10.1002/aoc.7421en_US
dc.identifier.issn0268-2605
dc.identifier.urihttps://doi.org/10.1002/aoc.7421
dc.identifier.urihttps://hdl.handle.net/11436/8888
dc.description.abstractIn this study, magnesium (II) phthalocyanines (2a, 3a) and their water-soluble derivatives (2b, 3b) were synthesized via multistep reactions. The structures of these phthalocyanines were identified by FT-IR, NMR, MALDI-TOF, and UV–Vis spectroscopy. The ct-DNA binding (UV–Vis absorption, competitive EB binding, and agarose electrophoresis studies) and supercoiled plasmid DNA nuclease properties (hydrolytic, photonuclease, oxidative nuclease, and photooxidative nuclease) of the water-soluble compounds were investigated using different methods. The DNA binding constant (Kb) values of 2b and 3b were calculated as 8.45 ± (0.25) × 104 and 7.71 ± (0.13) × 104 M−1 at 25°C, respectively. The results showed that 2b had a stronger ct-DNA binding effect than 3b according to Kb and r values. The DNA nuclease studies claimed that both compounds indicated photonuclease activity on plasmid DNA depending on the light dose. Additionally, 2b had a higher photonuclease capacity than 3b. All of these results showed that 2b had promising potential as a photosensitizer agent for photodynamic therapy.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnesiumen_US
dc.subjectPhotonucleaseen_US
dc.subjectPhthalocyanineen_US
dc.subjectPlasmid DNAen_US
dc.subjectSynthesisen_US
dc.titleNonperipherally and peripherally substituted water-soluble magnesium (II) phthalocyanines and their DNA binding, nuclease activitiesen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.contributor.institutionauthorKeleş, Turgut
dc.identifier.doi10.1002/aoc.7421en_US
dc.relation.journalApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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