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Efficient synthesis of 5-(substituted)benzyl-2,4-dihydro-3H-1,2,4-triazol- 3-ones using microwave irradiation
(2013)
A growing body of literature has shown the effectiveness of using microwave irradiation in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new 5-aryl-2,4-dihydro-3H-1,2,4- ...
Microwave-assisted synthesis of some novel benzimidazole derivatives containing imine function and evaluation of their antimicrobial activity
(Wiley, 2014)
4-Bromo-o-phenylenediamine and ethylimido-p-bromophenylacetate, 1, were subjected to microwave irradiation to synthesize benzimidazole derivative, compound 2. Ester derivative, 3, and hydrazide derivative, 4, of compound ...
Synthesis and molecular docking studies of novel triazole derivatives as antioxidant agents
(Bentham Science Publ Ltd, 2020)
A series of 1,2,4-triazole and 1,2,4- thiadiazole derivatives were prepared starting from ethyl 4-(3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzoate. Firstly, both ethyl ester groups were simultaneously transformed ...
Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors
(2023)
Background: Researchers seeking new drug candidates to treat diabetes mellitus have been exploring bioactive molecules found in nature, particularly tetrahydropyridines (THPs). Methods: A library of THPs (1–31) were ...
Studies on the protonation constants of some triazoles in ethanol-water mixtures
(Chemical Publishing Co., 2008)
Several studies, involving the formation and investigation of biological activities of some triazoles derivatives. These derivatives have weak acidic properties. To gain more information about the effect of solvent on ...
Microwave-assisted synthesis of some 1, 2, 4-triazol-3-ones and potentiometric determination of their pKa in amfiprotic and dipolar aprotic-water mixtures
(0-Belirlenecek, 2013)
The novel 5-alkyl(aryl)-4-(aryl)-2, 4-dihydro-3H-1, 2, 4-triazol-3-ones (1-12) were synthesized by reaction of (N?-ethoxycarbonyl)-4-alkyl(aryl)hydrazonic acid ethyl ester with primary amines by microwave irradiation. ...