Biyomühendislik Bölümü Koleksiyonu: Recent submissions
Now showing items 1-20 of 46
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Machine learning models for optimization, validation, and prediction of light emitting diodes with kinetin based basal medium for in vitro regeneration of upland cotton (Gossypium hirsutum L.)
(BioMed Central Ltd, 2025)Background: Plant tissue culture has emerged as a tool for improving cotton propagation and genetics, but recalcitrance nature of cotton makes it difficult to develop in vitro regeneration. Cotton's recalcitrance is ... -
Ultrasensitive analysis of BRCA-1 based on gold nanoparticles and molybdenum disulfide electrochemical immunosensor with enhanced signal amplification
(MDPI, 2025)The BRCA-1 protein, recognized for its diagnostic relevance in a wide spectrum of malignancies, has been the focus of extensive investigation. In this study, an electrochemical immunosensor specifically designed for BRCA-1 ... -
Bischalcone derivatives with fluorine and methoxy functional groups: Synthesis, molecular docking, and biological evaluation as potential anticancer agents
(Elsevier, 2025)The present study employed the Claisen-Schmidt condensation reaction to synthesize a series of bischalcones featuring fluorine atoms positioned at different positions in the B rings and 1,3,5-trimethoxy groups in the A ... -
Development of quasi-flexible solid polymer blend electrolytes and boron carbide reinforced tea waste electrodes for supercapacitors
(Elsevier, 2025)This study aims to create a prototype supercapacitor (SC) using free-standing-solid polymer electrolytes and tea waste (TW) doped boron carbide (B4C) electrodes. Quasi-solid polymer electrolyte (QSPE) films are made using ... -
An electrochemical immuno-cytosensor modified with nanofibers for the determination of a carcinoembryonic antigen
(Springer, 2024)In this study, La0.25Fe0.75FeO3 (PNp)perovskite nanoparticle was synthesized using the sol–gel method. PNp-coated polyacrylonitrile (PAN) nanofibers were prepared by electrospinning on the pencil graphite electrode (PGE) ... -
Determination of novel SARS-CoV-2 inhibitors by combination of machine learning and molecular modeling methods
(Bentham Science, 2023)Introduction: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor ... -
Mentha longifolia ssp. longifolia essential oil components as novel carbonic anhydrase isoform II and IX inhibitors: biological and molecular docking studies
(Bentham Science Publications, 2023)Background: Medicinal plant oils are used in the treatment of various human diseases due to their phytochemical components. Recently, enzyme inhibition studies have been increasing in cosmetics, the food industry, and ... -
Determination of exogenous adrenaline levels in patients undergoing cardiopulmonary resuscitation
(Amer Chemical Soc., 2023)Core-shell quantum dot ZnS/CdSe screen-printedelectrodeswere used to electrochemically measure human blood plasma levels ofexogenous adrenaline administered to cardiac arrest patients. Theelectrochemical behavior of ... -
Drug repositioning approach for the treatment of ankylosing spondylitıs
(Ankara University, 2022)Objective: In this study, it was aimed to determine an FDA-approved molecule that inhibits the IL-17 receptor, which is an important target for the prevention of inflammation in Ankylosing Spondylitis (AS), using the ... -
MS hastalığının tedavisine yönelik yeni Sfingosin-1-Fosfat reseptör modülatörlerinin geliştirilmesi
(Konya Teknik Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, 2022)Hesaplamalı ilaç tasarımı; ilaç geliştirme prosesini hızlandırmakla birlikte maliyeti de düşürerek tıp mühendisliğinin önde gelen alanlarından birine dönüşmüştür. MS hastalığı ölümle sonuçlanmasının yanı sıra, hastalarda ... -
Development of new cyclophilin d receptor inhibitors for the treatment of multiple sclerosis
(Ankara University, 2022)Objective: In this study, it was aimed to carry out computational studies for the development of new molecules for the inhibition of the cyclophilin D (CypD) receptor, which causes the disability of mitochondrial function ... -
In silico studies to develop new GSK3β inhibitors effective in the alzheimer's disease
(Bentham Science Publishers, 2022)Background: Alzheimer's disease affects a large part of the world’s population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment be-comes more and more important ... -
Synthesis, molecular docking and some metabolic enzyme inhibition properties of biphenyl-substituted chalcone derivatives
(Elsevier, 2022)The new synthesized biphenyl-substituted chalcone derivatives were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. ... -
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
(Taylor & Francis Ltd., 2022)The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure ... -
Synthesis, biological activities, antioxidant properties, and molecular docking studies of novel bis-schiff base podands as responsive chemosensors for anions
(Elsevier, 2022)In this study, bis-carbonyl podand (triethylene glycol bis(2-carbonylphenyl)ether) ( 1 ) was synthesized from the reaction of triethylene glycol dichloride with salicylaldehyde. Then, Schiff base podans ( 2 and 3 ) were ... -
Electrochemical properties of coumarin 500 encapsulated in a liquid crystal guided electrospun fiber core and their supercapacitor application
(Amer Chemical Soc., 2022)Here, we first report a study on coumarin 500 and liquid crystal including polyacrylonitrile nanofibers in terms of synthesis, characterizations, and supercapacitor performances. SEM, POM, FTIR, and DSC measurements showed ... -
Syntheses, crystal structures, hirshfeld surface analyses and electrochemical etoposide/camptotechin sensor applications of acetaldehyde oxime derivatives
(Elsevier, 2022)(E)-2-(4-Hydroxyphenyl)-2-oxoacetaldehyde oxime monohydrate (I) and (E)-2-(4 Nitropheny1)-2oxoacetaldehyde oximes (II) were synthesized from 4'-hydroxyacetophenone and 4'-nitroacetophenone, respectively. Their structures ... -
Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations
(Taylor & Francis Ltd., 2022)The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well. ... -
In silico studies to develop new GSK3 beta inhibitors effective in the 's disease
(Bentham Science Publications, 2022)Background: Alzheimer's disease affects a large part of the world's population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment becomes more and more important ... -
Development of MoS2 and Au nanoparticle including disposable CEA-based immuno-cytosensor platforms
(Springer, 2022)In this study, an electrochemical biosensor for determination of Carcinoembryonic antigen (CEA) biomarker using human breast ductal adenocarcinoma (MCF-7) and human ovarian adenocarcinoma (SK-OV-3) cancer cells was presented. ...
