• HSP inhibitor sensitize resistant MCF-7 cells to doxorubicin through suppressing HSP90AB4P pseudogene and HSPB1 expression 

  Coşkun, Kübra Açıkalın; Tutar, Lütfi; Abay, Elif Cansu; Gülüm, Levent; Çelik, Ayşe Büşranur; Gümüş, Mehmet; Koca, İrfan; Tutar, Yusuf (Bentham Science Publishers, 2025)

  Introduction: Doxorubicin, a first-line chemotherapeutic agent, often faces resistance in breast cancer subtypes, leading to treatment failure. HSPs (Heat shock proteins), especially HSP90, and their pseudogenes like ...

• Hi-labspermtracking: a novel and high-quality sperm tracking dataset with an advanced ensemble detection and tracking approach for real-world clinical scenarios 

  Aktaş, Abdulsamet; Serbes, Görkem; Uzun, Hakkı; Yiğit, Merve Hüner; Aydın, Nizamettin; İlhan, Hamza Osman (John Wiley and Sons Inc, 2025)

  Sperm motility, a critical factor in diagnosing male infertility, requires computer-based solutions due to the limitations of manual evaluation methods. This study introduces the Hi-LabSpermTracking dataset, comprising 66 ...

• Silodosin-induced anejaculation: a promising agent for male oral contraception 

  Sönmez, Berat; Uzun, Hakkı; Yiğit, Merve Hüner; Akça, Görkem; Dil, Eyüp; Orman, Erdem; Kaçan, Yakup (MRE Press, 2025)

  Background: The objective of this study was to investigate the feasibility of utilizing silodosin as a non-hormonal, reversible, oral contraceptive for men, alongside elucidating its mechanism of action pertaining to ...

• Phytochemical profiling and anticancer potential of pistachio wastes against MCF-7 breast cancer cells: a metabolic and apoptotic pathway analysis 

  Gülüm, Levent; Güler, Emrah; Zırhlı, Çağla Başak; Çelik, Ayşe Büşranur; Tutar, Yusuf (BioMed Central Ltd, 2025)

  Food waste poses significant environmental, economic, and social challenges worldwide. Pistachio waste is recognized for its health benefits, particularly for its anticancer properties. This study assessed the phytochemical ...

• Analysis of MMP-8, MMP-20, and TGF-β1 in molar-incisor hypomineralization and assessment of periodontal health 

  Bilgir, Başak Senian; Aydınoğlu, Sema; Arslan, İpek; Atak, Mehtap; Köse, Oğuz; Günaçar, Dilara Nil (BMC, 2025)

  Background: Gingival crevicular fluid (GCF) volume can be used to evaluate periodontal diseases, along with matrix metalloproteinase-8 (MMP-8) and transforming growth factor-beta 1 (TGF-β1) found in GCF. Conversely, matrix ...

• Somatostatin and N-acetylcysteine on testicular damage triggered by ischemia reperfusion: cellular protection and antioxidant effects 

  Çiftel, Enver; Mercantepe, Tolga; Çiftel, Serpil; Karakaş, Sibel Mataracı; Aktepe, Rıza; Yılmaz, Adnan; Mercantepe, Filiz (Springer Nature, 2025)

  Ischemia–reperfusion (I/R) injury is a significant cause of testicular damage, leading to infertility and other reproductive dysfunctions. Antioxidant therapies have emerged as a potential intervention to mitigate oxidative ...

• Can iron absorption in molasses be increased with probiotic additives? “molasses with increased bioavailability” 

  Yıldız, Yasin; Topçu, Atilla; Mercantepe, Tolga; Arpa, Medeni; Yıldız, İlknur Esen; Tümkaya, Levent (MDPI, 2025)

  Introduction: There are many studies on the chemical and enzymatic interactions of probiotics, and the effects of Lactobacillus plantarum 299v on iron absorption have been clearly shown. The aim of this study was to ...

• Effects of intermittent fasting on liver steatosis and fibrosis, serum FGF-21 and autophagy markers in metabolic dysfunction-associated fatty liver disease: a randomized controlled trial 

  Özlü Karahan, Tuğçe; Yılmaz Akyüz, Elvan; Yılmaz Karadağ, Demet; Yılmaz, Yusuf; Eren, Fatih (MDPI, 2025)

  Background: This randomized controlled study sought to determine the effect of intermittent fasting on anthropometric measurements, fibroblast growth factor (FGF)-21, and autophagy markers, as well as on hepatic steatosis ...

• Association of inflammatory and ischemic markers with posterior segment parameters in pseudoexfoliation syndrome and glaucoma 

  Satılmaz, Muhammed Fatih; Uzun, Feyzahan; Fındık, Hüseyin; Atak, Mehtap; Kaim, Muhammet; Okutucu, Murat; Aslan, Mehmet Gökhan (MDPI, 2025)

  Objective: This study aimed to investigate the structural, vascular, and biochemical alterations in patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PXG) and to evaluate the associations between ...

• The role of AMY1 gene copy number variation in dental caries susceptibility: insights from a Turkish population 

  Hatipoğlu, Ömer; Saydam, Faruk (Springer Nature, 2025)

  Objective: Dental caries is a multifactorial disease influenced by environmental, behavioral, and genetic factors. Recent studies suggest that variations in the AMY1 gene, which encodes salivary amylase, may contribute to ...

• Prognostic value of Aurora B expression in cancer patients: A meta-analysis 

  Hasan, Md. Mojahidur; Tory, Sehreen; Arslan, Yusuf Kemal; Saygideger, Yasemin; Tutar, Yusuf (SAGE Publications, 2025)

  Background: Overexpression of Aurora B is linked to poor prognosis in various malignancies; however, its prognostic role remains debatable. Conducting a meta-analysis is essential to reach a definitive conclusion. Methods: ...

• Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver 

  Cebi, Merve; Yılmaz, Yusuf (Frontiers Media SA, 2025)

  In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related ...

• In silico identification of LSD1 inhibition-responsive targets in small cell lung cancer 

  Nalkıran, İhsan; Nalkıran, Hatice Sevim; Özçelik, Neslihan; Kıvrak, Mehmet (MDPI, 2025)

  Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression, high metastatic potential, and limited therapeutic options. Lysine-specific demethylase 1 (LSD1) has been identified ...

• Exploring the prevalence and risk factors of MASLD in patients with newly diagnosed diabetes mellitus: a comprehensive investigation 

  Beyazal Polat, Hatice; Beyazal, Mehmet; Arpa, Medeni; Kızılkaya, Bayram; Ayaz, Teslime; Gündoğdu, Ömer Lütfi; Konur, Kamil; Polat, Zehra; Beyazal Çeliker, Fatma (MDPI, 2025)

  Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) represents a growing concern in the context of metabolic disorders, particularly among individuals diagnosed with type 2 diabetes mellitus (T2DM). ...

• Bis(azo-mine) based transition metal complexes: synthesis, spectroscopy, DNA binding, docking studies, and α-glucosidase inhibition activity 

  Zengin, Ali; Ertunga, Nagihan Sağlam; Akatın, Melike Yıldırım; Taşkın Tok, Tuğba; Ghaleb, Abdulmalek Hasan Mohammed; Ejder, Nebahat (John Wiley and Sons Ltd, 2025)

  In this work, two new mononuclear transition metal complexes: [M(L)], (M: Zn(II) for 2a, Mn(II) for 2b), with H2L (2,2′-{propane-1,3-diylbis[nitrilo(E)methylylidene]}bis{4-[(E)-phenyldiazenyl]phenol}, as the primary ligand ...

• Occurrence of antimicrobial resistance, integrons and virulence genes in Escherichia coli isolated from drinking water in Van, Turkiye: a cross-sectional study 

  Rakıcı, Erva; Aydın, Elif; Tanrıverdi, Elif Seren; Özgümüş, Osman Birol (BioMed Central Ltd, 2025)

  Background: Escherichia coli is one of the recommended freshwater indicator organisms for faecal contamination and can be associated with the pool of genes encoding antibiotic resistance. The aim of this study was to ...

• The use of stereological and electron microscopic techniques in the assessment of peripheral nerve regeneration success 

  Delibaş, Burcu (Elsevier, 2025)

  Morphological alterations in nerve tissue are commonly used as a hallmark in evaluating regeneration success in peripheral nerve studies. The use of stereological methods in the assessment of peripheral nerve and ganglion ...

• Metabolite-induced apoptosis by gundelia tournefortii in A549 lung cancer cells: A cytotoxic and gene expression study 

  Yüksel, Aysun; Celayir, Damla Nur; Tunoğlu, Ezgi Nurdan Yenilmez; Tutar, Lütfi; Tutar, Yusuf (MDPI, 2025)

  Background/Objectives: Gundelia tournefortii (Kenger) is a traditional medicinal plant and exhibits potential anticancer properties. This study investigates the cytotoxic and apoptotic effects of its water extract on human ...

• Predicting semen analysis parameters from testicular ultrasonography images using deep learning algorithms: an innovative approach to male infertility diagnosis 

  Sağır, Lütfullah; Kaba, Esat; Hüner Yiğit, Merve; Taşçı, Filiz; Uzun, Hakkı (MDPI, 2025)

  Objectives: Semen analysis is universally regarded as the gold standard for diagnosing male infertility, while ultrasonography plays a vital role as a complementary diagnostic tool. This study aims to assess the effectiveness ...

• The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome 

  Güleroğlu, Filiz Yarssilikal; Çetin, Ali; Coşkun, Göknil Pelin; Çalışkan, Meltem; Karaduman, Fulya; Bilginer, Can; Mısırlıoğlu, Reşat; Tekin, Sinem; Al, Merve Nur; Çaklılı, Tuğçe; Tutar, Yusuf (BMC, 2025)

  BackgroundPlacental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying ...

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