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The hepatoprotective effects of camellia sinensis on cisplatin-induced acute liver injury

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Tam Metin / Full Text (3.498Mb)

Erişim

info:eu-repo/semantics/openAccess

Tarih

2024

Yazar

Yılmaz, Adnan
Dizman, Fatih
Akyıldız, Kerimali
Mataracı Karakaş, Sibel
Mercantepe, Tolga
Uydu, Hüseyin Avni
Tümkaya, Levent
Öztürk, Köksal

Üst veri

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Künye

Yilmaz, A., Dizman, F., Akyildiz, K., Mataraci Karakas, S., Mercantepe, T., Uydu, H. A., Tumkaya, L., & Ozturk, K. (2024). The Hepatoprotective Effects of Camellia sinensis on Cisplatin-Induced Acute Liver Injury. Life, 14(9), 1077. https://doi.org/10.3390/life14091077

Özet

Acute liver injury is an increasing global health problem. It is a widespread side effect of cisplatin treatment in the clinic and can lead to liver failure if not treated promptly. Previous studies have revealed that green tea can protect some organs from treatments. However, the potential of white tea to prevent the negative effects of acute liver injury has not been addressed so far. The purpose of this study was to investigate the reduction in cisplatin-induced liver injury in rats receiving white tea. Female Sprague Dawley rats with similar weight were selected in this study. Twenty-four rats were divided into three groups of eight animals each and ad libitum nutrition was provided. The control and cisplatin groups were given tap water only, while the white tea + cisplatin group received white tea at a 0.5% weight/volume concentration for four weeks. At the end of the fourth week, the white tea + cisplatin group and the cisplatin group received a single dose of cisplatin (7 mg/kg) via the intraperitoneal route. Five days after that procedure, the rats were anesthetized. Liver tissues and blood samples were collected, which were used for biochemical and histopathological analyses. According to biochemical results, liver tissue MDA and GSH, serum ALT, and AST levels significantly increased in the cisplatin group compared to the control group. Compared with the cisplatin group, although MDA, AST, ALT, and GSH levels were lower in the white tea + cisplatin group, only GSH levels were statistically different. The examination of histopathological and immunohistochemical findings revealed apoptotic cells, vascular congestion, and sinusoidal dilatation in the cisplatin group compared to the control group. This adverse event decreased in the white tea + cisplatin group compared to the cisplatin group. In conclusion, white tea exhibits an ameliorating effect on cisplatin-induced liver injury.

Kaynak

Life

Cilt

14

Sayı

9

Bağlantı

https://doi.org/10.3390/life14091077
https://hdl.handle.net/11436/9588

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [5990]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [698]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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