dc.contributor.author | Okutucu, Murat | |
dc.contributor.author | Fındık, Hüseyin | |
dc.contributor.author | Aslan, Mehmet Gökhan | |
dc.contributor.author | Arpa, Medeni | |
dc.date.accessioned | 2020-12-19T19:32:14Z | |
dc.date.available | 2020-12-19T19:32:14Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Okutucu, M., Findik, H., Aslan, M. G., & Arpa, M. (2020). Is Netrin-1 Deficiency Responsible for Inflammation and Systemic Diseases Related to Pseudoexfoliation?. Journal of glaucoma, 29(11), 1077–1081. https://doi.org/10.1097/IJG.0000000000001624 | en_US |
dc.identifier.issn | 1057-0829 | |
dc.identifier.issn | 1536-481X | |
dc.identifier.uri | https://doi.org/10.1097/IJG.0000000000001624 | |
dc.identifier.uri | https://hdl.handle.net/11436/961 | |
dc.description | WOS: 000591398800014 | en_US |
dc.description | PubMed: 32769729 | en_US |
dc.description.abstract | Precis: Serum netrin-1 levels are significantly lower in patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PEG) compared with the control group. Purpose: To investigate serum netrin-1 levels in PES and PEG patients and to determine the relevance of this molecule in the etiopathogenesis of PES-related and PEG-related diseases. Materials and Methods: This prospective study included 29 PES and 17 PEG patients in the study groups and age-sex matched 47 cataract patients without pseudoexfoliative accumulation as a control group. Serum netrin-1 levels were measured by enzyme-linked immunosorbent assay. Results: Serum netrin-1 level was significantly lower in the PES and PEG groups compared with the control group (P=0.007). Multinominal logistic regression analysis was performed in terms of netrin-1 levels <= 712.9 pg/mL, >712.9 pg/mL and sex which may affect PES and PEG. It were found that netrin-1 was a significant negative predictor for PES (odds ratio, 3.45; 95% confidence interval, 1.230-9.716; P=0.019) and PEG (odds ratio, 3.57; 95% confidence interval, 1.008-12.669; P=0.049), respectively. Conclusions: Decreased serum netrin-1 levels were detected in PES and PEG patients, similar to atherosclerosis and Alzheimer disease. Inflammation lays behind in the common pathogenesis of these diseases. Therefore, netrin-1 promises a potential anti-inflammatory role. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pseudoexfoliation syndrome | en_US |
dc.subject | Pseudoexfliative glaucoma | en_US |
dc.subject | Netrin-1 | en_US |
dc.subject | Inflammation | en_US |
dc.title | Is netrin-1 deficiency responsible for inflammation and systemic diseases related to pseudoexfoliation? | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Okutucu, Murat | |
dc.contributor.institutionauthor | Fındık, Hüseyin | |
dc.contributor.institutionauthor | Aslan, Mehmet Gökhan | |
dc.contributor.institutionauthor | Arpa, Medeni | |
dc.identifier.doi | 10.1097/IJG.0000000000001624 | |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 1077 | en_US |
dc.identifier.endpage | 1081 | en_US |
dc.relation.journal | Journal of Glaucoma | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |