Konu "Rat" için listeleme
Toplam kayıt 106, listelenen: 1-20
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Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
(Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
(Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury
(Sage Publishing, 2012)The aim of this study was to investigate the possible protective effects of infliximab on oxidative stress, cell proliferation and apoptosis in the rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male ... -
Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion
(Springer Link, 2012)The purpose of this study was to investigate the role of infliximab on acute lung injury induced by intestinal ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: Sham, I/R and ... -
Antioxidative and anti-inflammatory effect of thymoquinone in an acute Pseudomonas Prostatitis Rat model
(KargerKarger, 2013)Introduction: the aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa. Material ... -
Benefits of the antioxidant and anti-inflammatory activity of etoricoxib in the prevention of ovarian ischemia/reperfusion injury induced experimentally in rats
(Wiley-Blackwell, 2014)Aim This study is a biochemical investigation of the effect of etoricoxib, a selective cyclooxygenase (COX)-2 inhibitor, on ischemia/reperfusion (I/R) injury experimentally induced in rat ovaries. Methods Experimental ... -
Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes
(Mashhad Univ Med Sciences, 2014)Objective(s): This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/ reperfusion (I/ R) injury in diabetic rats and evaluated oxidant and antioxidant marker ... -
Biochemical and histopathological investigation of liver tissues on high fat diet fed rats
(Galenos Yayıncılık, 2022)Objective: Hepatic steatosis is a common cause of liver disease and has become more prevalent recently. This study was conducted to investigate the biochemical and histopathological changes in the liver tissue high fat ... -
Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver
(2012)Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective ... -
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
(Springer, 2021)Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ... -
Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats?
(Taylor & Francis Ltd, 2015)We investigated the effects of a 900 Megahertz (MHz) electromagnetic field (EMF), applied during the prenatal period, on the spleen and thymus of 21-day-old male rat pups. Pregnant Sprague-Dawley rats were divided into ... -
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation
(Pergamon-Elsevier Science Ltd, 2015)Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain ... -
Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats
(Sage, 2009)Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their ... -
Comparative analysis of epigallocatechin-3-gallate and TNF-alpha inhibitors in mitigating cisplatin-induced pancreatic damage through oxidative stress and apoptosis pathways
(Springer, 2024)Oxidative stress and inflammation caused by cisplatin, which is frequently used in the treatment of many cancers, damage healthy tissues as well as cancer cells. In this study, we aimed to investigate the effect of ... -
A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue
(Pharmaceutical Soc Korea, 2013)In this study, the biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue were investigated. Animals were divided into four ... -
Comparative investigation of protective effects of metyrosine and metoprolol against ketamine cardiotoxicity in rats
(Humana Press Inc, 2015)This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. in this study, rats were divided into groups A, B and C. in group A, ... -
A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: biochemical and histopathological analysis
(Carbone Editore, 2014)Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether ... -
Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
(2012)The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are ... -
Damage induced by paracetamol compared with N-acetylcysteine
(Lippincott Williams & Wilkins, 2014)Background: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods: Rats for this experiment were divided into the following groups: ... -
The effect of acute organophosphate intoxication on female rat hippocampus cornu ammonis region pyramidal neuron numbers, biochemistry and morphology
(Elsevier, 2019)Background: the most commonly used insecticides and pesticides worldwide are organophosphate compounds, chemicals that irreversibly inhibit the cholinesterase enzyme. Acute intoxication with cholinesterase inhibitors is ...