Kurum Yazarı "Yılmaz, Yusuf" İçin Listeleme
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Hepatocyte apoptosis fragment product cytokeratin-18 M30 level and non-alcoholic steatohepatitis risk diagnosis: an international registry study
Zhang, Huai; Rios, Rafael S.; Boursier, Jerome; Anty, Rodolphe; Chan, Wah-Kheong; George, Jacob; Yılmaz, Yusuf; Wong, Vincent Wai-Sun; Fan, Jiangao; Dufour, Jean-Francois; Papatheodoridis, George; Chen, Li; Schattenberg, Joern M; Shi, Junping; Xu, Liang; Wong, Grace Lai-Hung; Lange, Naomi F.; Papatheodoridi, Margarita; Mi, Yuqiang; Zhou, Yujie; Byrne, Christopher D.; Targher, Giovanni; Feng, Gong; Zheng, Minghua (Lippincott Williams & Wilkins, 2023)Background:Liver biopsy for the diagnosis of non-alcoholic steatohepatitis (NASH) is limited by its inherent invasiveness and possible sampling errors. Some studies have shown that cytokeratin-18 (CK-18) concentrations may ... -
Impairment of patient-reported outcomes among patients with non-alcoholic fatty liver disease: a registry-based study
Yılmaz, Yusuf; Toraman, Ahmet Eren; Alp, Ceyda; Doğan, Zehra; Keklikkıran, Çağlayan; Stepanova, Maria; Younossi, Zobair (Wiley, 2022)Background Patients with non-alcoholic fatty liver disease (NAFLD) and more advanced fibrosis tend to have more impairment in their health-related quality of life and other patient-reported outcomes (PROs). Aim To assess ... -
An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease
Sun, Dan-Qin; Targher, Giovanni; Byrne, Christopher D.; Wheeler, David C.; Wong, Vincent Wai-Sun; Fan, Jian-Gao; Tilg, Herbert; Yuan, Wei-Jie; Wanner, Christoph; Gao, Xin; Long, Michelle T.; Kanbay, Mehmet; Nguyen, Mindie H.; Navaneethan, Sankar D.; Yılmaz, Yusuf; Huang, Yuli; Gani, Rino A.; Marzuillo, Pierluigi; Boursier, Jerome; Zhang, Huijie; Jung, Chan-Young; Chai, Jin; Valenti, Luca; Papatheodoridis, George; Musso, Giovanni; Wong, Yu-Jun; El-Kassas, Mohamed; Mendez-Sanchez, Nahum; Sookoian, Silvia; Pavlides, Michael; Duseja, Ajay; Holleboom, Adriaan G.; Shi, Junping; Chan, Wah-Kheong; Fouad, Yasser; Yang, Junwei; Treeprasertsuk, Sombat; Cortez-Pinto, Helena; Hamaguchi, Masahide; Romero-Gomez, Manuel; Al Mahtab, Mamun; Ocama, Ponsiano; Nakajima, Atsushi; Dai, Chunsun; Eslam, Mohammed; Wei, Lai; George, Jacob; Zheng, Ming-Hua (AME Publishing Company, 2023)Background: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition with chronic kidney disease (CKD) has become increasingly evident. In ... -
An international multidisciplinary consensus statement on MAFLD and the risk of CVD
Zhou, Xiao-Dong; Targher, Giovanni; Byrne, Christopher D.; Somers, Virend; Kim, Seung Up; Chahal, C. Anwar A.; Wong, Vincent Wai-Sun; Cai, Jingjing; Shapiro, Michael D.; Eslam, Mohammed; Steg, Philippe Gabriel; Sung, Ki-Chul; Misra, Anoop; Li, Jian-Jun; Brotons, Carlos; Huang, Yuli; Papatheodoridis, George V.; Sun, Aijun; Yılmaz, Yusuf; Chan, Wah Kheong; Huang, Hui; Mendez-Sanchez, Nahum; Alqahtani, Saleh A.; Cortez-Pinto, Helena; Lip, Gregory Y. H.; de Knegt, Robert J.; Ocama, Ponsiano; Romero-Gomez, Manuel; Fudim, Marat; Sebastiani, Giada; Son, Jang Won; Ryan, John D.; Ikonomidis, Ignatios; Treeprasertsuk, Sombat; Pastori, Daniele; Lupsor-Platon, Monica; Tilg, Herbert; Ghazinyan, Hasmik; Boursier, Jerome; Hamaguchi, Masahide; Nguyen, Mindie H.; Fan, Jian-Gao; Goh, George Boon-Bee; Al Mahtab, Mamun; Hamid, Saeed; Perera, Nilanka; (George, Jacob; Zheng, Ming-Hua (Springer, 2023)Background Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of similar to 25-30% and is also associated with cardiovascular disease (CVD). ... -
A multi-society Delphi consensus statement on new fatty liver disease nomenclature
Rinella, Mary, E.; Lazarus, Jeffrey V.; Ratziu, Vlad; Francque, Sven M.; Sanyal, Arun J.; Kanwal, Fasiha; Romero, Diana; Abdelmalek, Manal; Anstee, Quentin M.; Arab, Juan Pablo; Arrese, Marco; Bataller, Ramon; Beuers, Ulrich; Boursier, Jerome; Bugianesi, Elisabetta; Byrne, Christopher D.; Castro Narro, Graciela E.; Chowdhury, Abhijit; Cortez-Pinto, Helena; Cryer, Donna; Cusi, Kenneth; El-Kassas, Mohamed; Klein, Samuel; Eskridge, Wayne; Fan, Jiangao; Gawrieh, Samer; Guy, Cynthia D.; Harrison, Stephen A.; Kim, Seung Up; Koot, Bart; Korenjak, Marko; Kowdley, Kris; Lacaille, Florence; Loomba, Rohit; Mitchell Thain, Robert; Morgan, Timothy R.; Powell, Elisabeth; Roden, Michael; Romero-Gomez, Manuel; Silva, Marcelo; Prasad Singh, Shivaram; Sookoian, Silvia C.; Spearman, C. Wendy; Tiniakos, Dina; Valenti, Luca; Vos, Miriam B.; Wong, Vincent Wai-Sun; Xanthakos, Stavra; Yılmaz, Yusuf; Younossi, Zobair; Hobbs, Ansley; Villota-Rivas, Marcela; Newsome, Philip N.; NAFLD Nomenclature consensus group (Elsevier, 2023)The principal limitations of the terms nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. ... -
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Rinella, Mary E.; Lazarus, Jeffrey V.; Ratziu, Vlad; Francque, Sven M.; Sanyal, Arun J.; Kanwal, Fasiha; Romero, Diana; Abdelmalek, Manal F.; Anstee, Quentin M.; Arab, Juan Pablo; Arrese, Marco; Bataller, Ramon; Beuers, Ulrich; Boursier, Jerome; Bugianesi, Elisabetta; Byrne, Christopher D.; Castro Narro, Graciela E.; Chowdhury, Abhijit; Cortez-Pinto, Helena; Cryer, Donna R.; Cusi, Kenneth; El-Kassas, Mohamed; Klein, Samuel; Eskridge, Wayne; Fan, Jiangao; Gawrieh, Samer; Guy, Cynthia D.; Harrison, Stephen A.; Kim, Seung Up; Koot, Bart G.; Korenjak, Marko; Kowdley, Kris V.; Lacaille, Florence; Loomba, Rohit; Mitchell-Thain, Robert; Morgan, Timothy R.; Powell, Elisabeth E.; Roden, Michael; Romero-Gómez, Manuel; Silva, Marcelo; Singh, Shivaram Prasad; Sookoian, Silvia C.; Spearman, C. Wendy; Tiniakos, Dina; Valenti, Luca; Vos, Miriam B.; Wong, Vincent Wai-Sun; Xanthakos, Stavra; Yılmaz, Yusuf; Younossi, Zobair; Hobbs, Ansley; Villota-Rivas, Marcela; Newsome, Philip N. (Elsevier, 2023)The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient ... -
Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
Pennisi, Grazia; Enea, Marco; Falco, Vincenzo; Aithal, Guruprasad P.; Palaniyappan, Naaventhan; Yılmaz, Yusuf; Boursier, Jerome; Cassinotto, Christophe; De Lédinghen, Victor; Chan, Wah Kheong; Mahadeva, Sanjiv; Eddowes, Peter; Newsome, Philip; Karlas, Thomas; Wiegand, Johannes; Wong, Vincent Wai-Sun; Schattenberg, Jörn M.; Labenz, Christian; Kim, Won; Lee, Myoung Seok; Lupsor-Platon, Monica; Cobbold, Jeremy F. L.; Fan, Jian-Gao; Shen, Feng; Staufer, Katharina; Trauner, Michael; Stauber, Rudolf; Nakajima, Atsushi; Yoneda, Masato; Bugianesi, Elisabetta; Younes, Ramy; Gaia, Silvia; Zheng, Ming-Hua; Cammà, Calogero; Anstee, Quentin M.; Mózes, Ferenc E.; Pavlides, Michael; Petta, Salvatore (Wolters Kluwer Medknow Publications, 2023)Background and Aims: We evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in NAFLD patients with type 2 diabetes (T2D). Methods and Results: This was an individual patient data meta-analysis of 1780 ... -
Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease and type 2 diabetes
Pennisi, Giovanni; Enea, Morgane; Falco, Vincenzo; Aithal, Guruprasad P.; Palaniyappan, Naaventhan; Yılmaz, Yusuf; Boursier, Jerome; Cassinotto, Christophe; De Lédinghen, Victor; Chan, Wah Kheong; Mahadeva, Sanjiv; Eddowes, Peter; Newsome, Philip; Karlas, Thomas; Wiegand, Johannes; Wong, Vincent Wai-Sun; Schattenberg, Jörn M.; Labenz, Christian; Kim, Won; Lee, Myoung Seok; Lupsor-Platon, Monica; Cobbold, Jeremy F. L.; Fan, Jian-Gao; Shen, Feng; Staufer, Katharina; Trauner, Michael; Stauber, Rudolf; Nakajima, Atsushi; Yoneda, Masato; Bugianesi, Elisabetta; Younes, Ramy; Gaia, Silvia; Zheng, Ming-Hua; Cammà, Calogero; Anstee, Quentin M.; Mózes, Ferenc E.; Pavlides, Michael; Petta, Salvatore (Elsevier, 2023)Background The aim of this study was to evaluate the diagnostic accuracy of simple non-invasive tests (NITs) in NAFLD patients with type 2 diabetes(T2D). Methods This was an individual patient data meta-analysis of ... -
Pathogenetic pathways in nonalcoholic fatty liver disease: An incomplete jigsaw puzzle
Pan, Qin; Fan, Jian-Gao; Yılmaz, Yusuf (Elsevier, 2023)Multiple pathways including insulin signaling, JNK1/2 of MAPK signaling, GLP-1R signaling, and NRs affect to maintain the homeostasis of lipid metabolism in normal liver. ERK1/2 and P38 of MAPK signaling pathway antagonistically ... -
A phase 3 trial of seladelpar in primary biliary cholangitis
Hirschfield, Gideon M.; Bowlus, Christopher L.; Mayo, Marlyn J.; Kremer, Andreas E.; Vierling, John M.; Kowdley, Kris V.; Levy, Cynthia; Villamil, Alejandra; Ladrón de Guevara Cetina, Alma L.; Janczewska, Ewa; Zigmond, Ehud; Jeong, Sook-Hyang; Yılmaz, Yusuf; Kallis, Yiannis; Corpechot, Christophe; Buggisch, Peter; Invernizzi, Pietro; Hurtado, Maria Carlota Londoño; Bergheanu, Sandrin; Yang, Ke; Choi, Yun-Jung; Crittenden, Daria B.; McWherter, Charles A. (Massachussetts Medical Society, 2024)Effective treatments for patients with primary biliary cholangitis are limited. Seladelpar, a peroxisome proliferator–activated receptor delta agonist, has potential benefits. METHODS In this phase 3, 12-month, double-blind, ... -
Predicting fibrosis progression in non-alcoholic fatty liver disease patients using the FAST Score: A paired biopsy study
Sarıyar, Nisanur; Kani, Haluk Tarık; Çelikel, Çiğdem Ataizi; Yılmaz, Yusuf (Kare Publishing, 2024)Background and Aim: This study aimed to investigate the predictive value of various non-invasive scores for identifying the progression of hepatic fibrosis over time in patients with Non-Alcoholic Fatty Liver Disease ... -
Prevalence of metabolic dysfunction-associated steatotic liver disease in the Middle East and North Africa
Younossi, Zobair M.; Golabi, Pegah; Paik, James; Owrangi, Soroor; Yılmaz, Yusuf; El-Kassas, Mohamed; Alswat, Khalid; Alqahtani, Saleh A. (Wiley, 2024)Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is common and closely associated with type 2 diabetes (T2D). We assessed ... -
Prevalence, determinants, and fibrosis risk stratification of metabolic-associated fatty liver disease in a Turkish primary care setting: A retrospective study
Arslan, Ayşe Yazan; Çelik, Sultannur; Amin, Fatuhulah; Çaylak, İlayda; Kesaplı, İrem; Kılıç, İbrahim Berke; Karakullukcu, Serdar; Ardıç, Cüneyt; Yılmaz, Yusuf (Kare Publishing, 2023)Background and Aim: Metabolic-associated fatty liver disease (MAFLD) is a condition that frequently goes unnoticed as it typically remains asymptomatic until progressing to an advanced stage. As a result, it is essential ... -
Real-world evidence on non-invasive tests and associated cut-offs used to assess fibrosis in routine clinical practice
Lazarus, Jeffrey V.; Castera, Laurent; Mark, Henry E.; Allen, Alina M.; Adams, Leon A.; Anstee, Quentin M.; Arrese, Marco; Alqahtani, Saleh A.; Bugianesi, Elisabetta; Colombo, Massimo; Cusi, Kenneth; Hagström, Hannes; Loomba, Rohit; Romero-Gomez, Manuel; Schattenberg, Jörn M.; Thiele, Maja; Valenti, Luca; Wai-Sun Wong, Vincent; Yılmaz, Yusuf; Younossi, Zobair M.; Francque, Sven M.; Tsochatzis, Emmanuel A. (Elsevier, 2022)Background & Aims: Non-invasive tests (NITs) offer a practical solution for advanced fibrosis identification in non-alcoholic fatty liver disease (NAFLD). Despite increasing implementation, their use is not standardised, ... -
Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Feng, Gong; Valenti, Luca; Wong, Vincent Wai-Sun; Fouad, Yasser Mahrous; Yılmaz, Yusuf; Kim, Won; Sebastiani, Giada; Younossi, Zobair M.; Hernandez Gea, Virginia; Zheng, Ming-Hua (SpringerNature, 2023)Recompensation has gained increasing attention in the feld of cirrhosis, particularly in chronic liver disease with a defnite aetiology. The current global prevalence of obesity and nonalcoholic fatty liver disease (NAFLD) ... -
The risk of development of primary biliary cholangitis among incidental antimitochondrial M2 antibody-positive patients
Ergenç, İlkay; Gözaydınoğlu, Büşra; Keklikkıran, Çağlayan; Yılmaz, Yusuf (Kare Publishing, 2023)Background and Aim: This study investigated the risk of the development of primary biliary cholangitis (PBC) in individuals who were incidentally identified as having positive antimitochondrial antibodies (AMA)-M2.Materials ... -
The role of FibroScan in the era of metabolic (dysfunction)-associated fatty liver disease
Yılmaz, Yusuf; Kaya, Eda (Kare Publishing, 2023)Among chronic liver conditions, metabolic (dysfunction)-associated fatty liver disease (MAFLD) ranks as the most frequent. With a worldwide prevalence of 37%, the global burden of MAFLD is large and growing. -
TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease
Yılmaz, Yusuf; Zeybel, Müjdat; Adalı, Gupse; Coşar, Arif Mansur; Sertesen, Elif; Gökcan, Hale; Bahçecioğlu, Halil İbrahim; Şahin, Mustafa; Tulunay, Cansın; Ergun, İhsan; Turan, İlker; İdilman, İlkay Sedatak; Çelikel, Çiğdem; Kırımlıoğlu, Hale; Akyol, Gülen; Yılmaz, Funda; Sökmensuer, Cenk; Güveli, Hakan; Akarca, Ulus Salih; Akyüz, Ümit; Genç, Volkan; Akyıldız, Murat; Yazıhan, Nuray; Tutar, Engin; Ateş, Fehmi; Dinçer, Dinç; Balaban, Yasemin; Kıyıcı, Murat; Akdoğan, Meral; Sonsuz, Abdullah; İdilman, Ramazan (Kare Publishing, 2023)Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become ... -
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study
Anstee, Quentin M.; Lucas, Kathryn J.; Francque, Sven; Abdelmalek, Manal F.; Sanyal, Arun J.; Ratziu, Vlad; Gadano, Adrian C.; Rinella, Mary; Charlton, Michael; Loomba, Rohit; Mena, Edward; Schattenberg, Jörn M.; Noureddin, Mazen; Lazas, Donald; Goh, George B.B.; Sarin, Shiv K.; Yılmaz, Yusuf; Martic, Miljen; Stringer, Rowan; Kochuparampil, Jossy; Chen, Li; Rodriguez-Araujo, Gerardo; Chng, Elaine; Naoumov, Nikolai V.; Brass, Clifford; Pedrosa, Marcos C. (Wolters Kluwer Medknow Publications, 2023)Background and Aims: With distinct mechanisms of action, the combination of tropifexor (TXR) and cenicriviroc (CVC) may provide an effective treatment for NASH. This randomized, multicenter, double-blind, phase 2b study ...