Yazar "Topçu, Atilla" için listeleme
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Effects of oral zinc administration on long-term ipsilateral and contralateral testes damage after experimental testis ischaemia-reperfusion
Oral, Akgün; Halıcı, Zekai; Bayır, Yasin; Topçu, Atilla; Un, Harun; Bilgin, Aslı Özbek; Atmaca, Hasan Tarık (Wiley, 2017)The purpose of this study was to examine potential long-term post-torsion changes that can occur in the histopathology, biochemistry and spermatogenesis of both torsioned and nontorsioned opposite testes. the study also ... -
The effects of vitamin B12 on the TLR-4/NF-κB signaling pathway in ovarian ischemia-reperfusion injury-related inflammation
Deniz, Esra; Topçu, Atilla; Öztürk, Aykut; Öztürk, Seda Duman; Arpa, Medeni; Atak, Mehtap (Elsevier, 2022)Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress and inflammation play central roles in the development of ischemia/reperfusion injuries. We investigated the ... -
The effects of white tea (Camellia Sinensis) and infliximab against cisplatin-induced testicular damage via oxidative stress and apoptosis
Çakıroğlu, Şenay; Mercantepe, Tolga; Tümkaya, Levent; Uydu, Hüseyin Avni; Topçu, Atilla; Atak, Mehtap (2023)Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, ... -
Evaluation of the protective effect of coenzyme Q10 against x-ray irradiation-induced ovarian injury
Tekin, Yeşim Bayoğlu; Tümkaya, Levent; Mercantepe, Tolga; Topal, Zehra Suzan; Samancı, Tuğba Çelik; Yılmaz, Hülya Kılıç; Rakıcı, Sema Yılmaz; Topçu, Atilla (Wiley, 2024)Aim: This study focused on the anti-oxidant and anti-apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation. Methods: Thirty-two female rats were randomly assigned into four groups. Group I (control group), Group ... -
Hedera helix folium extract attenuates methotrexate-induced hepatotoxicity by modulating oxidative stress and inflammatory mediators
Deniz, Esra; Topçu, Atilla; Öztürk, Aykut; Öztürk, Seda Duman; Akyıldız, Kerimali (Elsevier, 2025)Methotrexate (MTX)-induced hepatotoxicity is linked to oxidative damage and inflammatory processes. Hedera helix folium (HHF) extract protects cells against oxidative damage. We investigated the role of HHF extract in tumor ... -
Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers
Halıcı Zekai; Polat, Beyzagül; Çadırcı, Elif; Topçu, Atilla; Karakuş, Emre; Köse, Duygu; Albayrak, Abdülmecit; Bayır, Yasin (Elsevier Ireland Ltd, 2016)Purpose: Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin ... -
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats
Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ... -
An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats
Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ... -
Is punica granatum efficient against sepsis? A comparative study of amifostine versus pomegranate
Şahin, Kazım; Şahin Aktura, Sena; Bahçeci, İlkay; Mercantepe, Tolga; Tümkaya, Levent; Topçu, Atilla; Mercantepe, Filiz; Duran, Ömer Faruk; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (MDPI, 2025)Sepsis is a clinical condition causing tissue damage as a result of infection and an exaggerated immune response. Sepsis causes 11 million deaths annually, a third of which are associated with acute lung injury (ALI). Rapid ... -
Is there any correlation between levels of serum ostepontin, CEA, and FDG uptake in lung cancer patients with bone metastasis?
Ayan, Arif Kürşad; Erdemci, Burak; Örsal, Ebru; Bayraktutan, Zafer; Akpınar, Elif; Topçu, Atilla; Türkeli, Mehmet; Seven, Bedri (Elsevier Espana Slu, 2016)Objective: in this study, an evaluation was made of the relationship between the serum levels of carcinoembryonic antigen (CEA), osteopontin (OPN), and the semi-quantitative parameters of 18-fluoro2-deoxyglucose positron ... -
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
Aktepe, Rıza; Üçüncü, Yılmaz; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Uydu, Hüseyin Avni; Atak, Mehtap (Elsevier, 2024)Ovarium torsion is a gynecological emergency that is common in women of reproductive age and requires early diagnosis and intervention. In this study, we aimed to investigate the long-term anatomical, histological and ... -
The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation
Batçık, Şule; Tümkaya, Levent; Mercantepe, Tolga; Atak, Mehtap; Topçu, Atilla; Uydu, Hüseyin Avni; Mercantepe, F. (Verduci Editore, 2022)OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ... -
The nephroprotective effect of punica granatum peel extract on LPS-induced acute kidney injury
Şahin Aktura, Sena; Şahin, Kazım; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Pınarbaş, Esra; Yazıcı, Zihni Açar (MDPI, 2024)Sepsis is an exaggerated immune response resulting from systemic inflammation, which can damage tissues and organs. Acute kidney injury has been detected in at least one-third of patients with sepsis. Sepsis-associated ... -
A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine
Karaman, Adem; Diyarbakır, Büşra; Durur-Subaşı, Irmak; Köse, Duygu; Özbek-Bilgin, Aslı; Topçu, Atilla; Gündoğdu, Cemal; Durur-Karakaya, Afak; Bayraktutan, Zafer; Alper, Fatih (British Inst Radiology, 2016)Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). the drug's action on the antioxidant system and proinflammatory cytokines, ... -
Positive effects of white tea on breast cancer: N-methyl-N-nitrozourea intraductal induced breast carcinoma model
Mataracı Karakaş, Sibel; Yılmaz, Adnan; Mercantepe, Tolga; Topçu, Atilla; Pınarbaş, Esra (Elsevier, 2024)An objective of this study was to investigate the chemopreventive and therapeutic effects of white tea (WT) on breast cancer. Fifty Sprague-Dawley rats were divided into five groups: control, MNU, taxol, low dose white tea ... -
Protective effect of tea grape extract on cisplatin-induced muscle atrophy: A morphological study
Balık, Mehmet Sabri; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Balık, Gülşah; Topçu, Atilla; Yazıcı, Zihni Açar (Kowsar Publ, 2018)Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of ... -
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
Mercantepe, Filiz; Mercantepe, Tolga; Topçu, Atilla; Yılmaz, Adnan; Tümkaya, Levent (Springer, 2018)Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ... -
The protective effects of angiotensin-converting enzyme inhibitor against cecal ligation and puncture-induced sepsis via oxidative stress and inflammation
Kostakoğlu, Uğur; Topçu, Atilla; Atak, Mehtap; Tümkaya, Levent; Mercantepe, Tolga; Uydu, Hüseyin Avni (Pergamon-Elsevier Science Ltd, 2020)Aims: Sepsis is a severe public health problem affecting millions of individuals, with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory ... -
Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat
Çolak, Sabri; Gürlek, Beril; Topçu, Atilla; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Wiley, 2020)Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ...
