Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Development of eco-friendly activated carbon from olive pits for the adsorption of tartrazine with isotherm kinetic and thermodynamic studies
(Nature Publishing Group, 2026) Remil, Abderrahmane; Reguig, Abdelkrim Bendoukha; Saidi, Mokhtar; Bouchama, Abdelghani; Monir, Mohammed El Amine; Fatmi, M.; Yaylacı, Murat
Synthetic dyes discharged into water bodies pose a persistent environmental threat owing to their resistance to natural degradation, toxicity, and long-term ecological impact. In this study, discarded olive pits were valorized as a lignocellulosic precursor for the production of activated carbon through phosphoric acid activation. Multiple analytical tools including pHpzc, FTIR, SEM, XPS, and XRD-were used to examine the structural, physicochemical, and morphological characteristics of the prepared material. The influence of key process variables on Tartrazine uptake was assessed through a series of batch-mode experiments, including pH, initial dye concentration, adsorbent dose, contact time, and temperature. Maximum adsorption was achieved in acidic medium (pH = 2) using an adsorbent dose of 40 mg, an initial Tartrazine concentration of 40 mg L-1, a contact time of 24 h, and a temperature of 298 K. The maximum adsorption capacity reached 47.18 mg g-1 according to the BET model, while the pseudo-second-order kinetic model provided the best fit (R2 = 0.9996) with an experimental Qe value of 31.39 mg g-1. Thermodynamic parameters (ΔH° = - 10328 J mol-1; ΔG° = - 1409 to - 1794 J mol-1) confirmed that the process is exothermic and spontaneous. The results of the pseudo-second-order kinetic model and Thermodynamic analysis showed that the process is a mixed adsorption mechanism dominated by physisorption. These findings collectively establish H3PO4-activated olive pit carbon as a high-performance, cost-effective, and environmentally viable material for Tartrazine decontamination from water matrices.
Effects of brewing conditions on the sensory and chemical properties of Turkish black tea and their interrelationships
(Nature Publishing Group, 2026) Cho, Jung Min; Yavuz Abanoz, Yasemin; Boyraz, Aslı; Demir, Adem; Çavuş, Derya; Çapoğlu, Havva Er; Başaran, Burhan
This study investigated the effects of different brewing conditions on the sensory and chemical properties of Turkish black tea and examined the relationships among the related parameters. The brewing variables evaluated were teapot type, brewing method, teapot spout condition, brewing time, and brewing water temperature. The brewed tea samples were evaluated by seven trained panelists for colour, astringency, and flavour and analysed for major chemical quality parameters, including total phenolic content (TPC), caffeine, theaflavins (TF), thearubigins (TR), brew colour indices, and L*a*b values. A total of 2,688 cups of brewed black tea were prepared, of which 672 were control and 2,016 were test samples, and were evaluated by seven trained panelists. Among the sensory attributes, colour was the most responsive parameter, being significantly affected by teapot type and brewing water temperature (p < 0.01), whereas astringency and flavour were not significantly influenced by the tested brewing conditions. In the chemical analyses, brewing water temperature was the most influential factor, significantly affecting TPC, caffeine, TF, TR, total colour in the brew, brightness in the brew, and a* (p < 0.01). Teapot type, brewing method, teapot spout condition, and brewing time also showed selective effects on specific chemical variables. Correlation analysis further showed that sensory colour was positively associated with TPC, caffeine, TF, TR, brightness in the brew, and total colour in the brew (p < 0.01), whereas astringency and flavour showed limited or no direct associations with the analysed chemical parameters. By examining Turkish-style brewing variables together with sensory and chemical profiling, this study provides novel evidence on sensory-chemical relationships in black tea and offers practical guidance for optimising brewing conditions in research and traditional tea preparation.
Investigation of the effects of antivirals used in hepatitis B treatment on blood lipid profile: a retrospective real-life data analysis
(Torino : Minerva Medica, 2026) Karabay, Oğuz; Kabukcu, Seda; Güçlü, Ertuğrul; Zerdali, Esra; Önlen, Yusuf; Yıldız, İlknur Esen; Tabak, Fehmi
Background: Entecavir (ETV), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are widely used in the treatment of chronic hepatitis B (CHB). This study aimed to investigate the blood lipid profile of CHB patients using these three drugs.
Methods: This Türkiye-wide retrospective cohort study included individuals who were older than 18 years of age, treatment-naive and were diagnosed with CHB for at least 1 year after 2010. The study aimed to evaluate the 48-month lipid profile changes of patients taking antivirals.
Results: In total, 1912 cases (ETV 756 [39.3%], TDF 1082 [56.3%] and TAF 74 [3.8%]) diagnosed with CHB and receiving antiviral treatment were included. There was no difference between the three drug groups in terms of age and comorbidities (P>0.05). While there was no difference in the initial total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TG) values between the three groups, all values were significantly lower in the TDF group in the first year (P<0.05). While TG, LDL and TC values were significantly lower in the TDF group in the second year (P<0.05), there was no difference in HDL and HDL/CHOL (P>0.05).
Conclusions: TDF causes a decrease in LDL levels, TC and total cholesterol/HDL ratio. However, use of ETV and TAF did not significantly affect the lipid profile. It should not be forgotten that lipid profile changes may cause metabolic health problems in individuals receiving hepatitis B treatment and appropriate treatment should be planned by regular monitoring according to treatment groups.
Bayesian hierarchical modelling of root canal morphology in mandibular first premolars across 21 countries
(Oxford, Blackwell Scientific Publications, 2026) Hatipoğlu, Fatma Pertek; Magat, Güldane; Karobari, Mohmed Isaqali; Buchanan, Glynn Dale; Kopbayeva, Maira; Taha, Nessrin; Hatipoğlu, Ömer
Background: Understanding root canal morphology is crucial for successful endodontic treatment; however, the anatomy of mandibular first premolars (M1Ps) remains one of the most variable and challenging aspects. The Vertucci classification provides a standardised framework for describing canal configurations; however, population-level data integrating multiple countries are scarce. This study aimed to evaluate the global distribution and determinants of Vertucci canal morphology in M1Ps using a Bayesian hierarchical model.
Methods: Cone-beam computed tomography (CBCT) data of M1Ps from 21 countries were analysed. The Vertucci classification was used as the categorical outcome variable. The predictors included tooth side (34/44), voxel size, field of view (FOV), sex and age, with the country modelled as a random intercept. A Bayesian hierarchical multinomial logistic regression was fitted using the brms package (rstan backend) with weakly informative priors. Posterior estimates were expressed as odds ratios (OR) and 95% credible intervals (CrI), and model-based predicted probabilities were computed for each Vertucci type.
Results: Bayesian modelling estimated the posterior probability of Vertucci Type I configuration at 73.4% (95% CrI: 63.8%-81.5%). Non-Type I configurations showed lower but credible probabilities, including Type V (8.2%, 3.6%-15.9%), Type III (3.7%, 1.6%-7.7%), Type IV (2.9%, 1.2%-6.3%) and Type II (1.3%, 0.5%-3.1%). Unclassified canal patterns accounted for approximately one-tenth of the MnP1s (9.9%, 3.9%-19.2%). Substantial variability was observed between countries for non-Type I and unclassified configurations, whereas Type I remained consistently predominant. Sex and age exerted modest effects, whereas tooth side and field of view showed no meaningful associations. Increasing the voxel size was associated with a slight reduction in the probability of Type I and marginal increases in Type V and unclassified configurations.
Conclusions: Although Vertucci Type I configuration predominates globally in MnP1s, clinically relevant non-Type I and unclassified canal patterns occur with non-negligible frequency and vary across populations. Bayesian hierarchical modelling enables the robust quantification of anatomical heterogeneity and uncertainty, supporting more reliable cross-country comparisons and cautious interpretation of less common canal configurations.
Coenzyme Q10 protects against 6 GHz electromagnetic field-induced liver injury via suppression of inflammatory responses associated with NF-κB/p65 immunoreactivity and endoplasmic reticulum stress
(Nature Publishing Group, 2026) Akyıldız, Kerimali; Yılmaz, Hamit; Yılmaz, Adnan; Mercantepe, Tolga; Gül, Fatih; Tümkaya, Levent
We evaluated endoplasmic reticulum stress responses in hepatic tissues following 6 GHz electromagnetic field (EMF) exposure and the protective effects of Coenzyme Q10 (CoQ10). The experimental design included 24 male Sprague-Dawley rats randomly assigned to three groups: (i) sham control group, (ii) 6 GHz EMF exposure group, and (iii) 6 GHz EMF exposure + CoQ10 treatment group. Rats in the exposure groups were subjected to 6 GHz EMF exposure for 2 h/day over 30 consecutive days. Rats in the exposure groups were subjected to 6 GHz EMF exposure (0.21 mW/cm2; specific absorption rate: 0.014 W/kg) for 2 h/day over 30 consecutive days. In addition, the animals in the CoQ10 treatment group received CoQ10 orally at a dose of 10 mg/kg/day throughout the exposure period. After completing the experimental protocol, hepatic tissue samples were obtained for subsequent analyses. Comparative analyses revealed significant differences in TBARS, GSH, TNF-α, IL-1β, ALT, and AST levels across the control-6 GHz and 6 GHz -6 GHz + CoQ10 groups. Exposure to 6 GHz EMF increased histopathological damage and liver histopathological score values, whereas CoQ10 markedly reduced these changes and suppressed glucose-regulated protein 78, C/EBP homologous protein, oxidative 8-hydroxy-2'-deoxyguanosine, and nuclear factor kappa B p65immunoreactivitiesy. 6 GHz EMF induces hepatic dysfunction via oxidative stress, endoplasmic reticulum stress, inflammation, and DNA damage, whereas CoQ10 mitigates these effects of EMF exposure.
