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Inhibition of O6-methylguanine-DNA-methyltransferase (MGMT) by lomeguatrib reduces multiple myeloma cell viability and impairs DNA repair in MGMT-proficient cells
Akçora Yıldız, Dilara; Özkan, Tülin; Çetintav, Bekir; Yükselten, Yunus; Çalış, Şeyma; Nalkıran, Hatice Sevim; Türkel, Nezaket; Gündüz, Mehmet; Özen, Mehmet; Beksaç, Meral; Sunguroğlu, Asuman (Wiley, 2024)The function of direct DNA damage repair protein, namely MGMT in MM, and the impact of MGMT on melphalan treatment remains unclear. We showed a significantly higher MGMT mRNA expression in CD138+ myeloma cells than in ...
