Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Effectiveness, safety, and treatment satisfaction of 20% subcutaneous immunoglobulin replacement therapy in pediatric patients with primary and secondary immunodeficiencies
(AVES, 2025) Sefer, Asena Pınar; Kaya, Mehmet Şirin
Objective: Primary immunodeficiencies (PID) and secondary immunodeficiencies (SID) increase the risk of severe and recurrent infections. Immunoglobulin replacement therapy (IGRT) is essential for these patients, administered as intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG). Subcutaneous immunoglobulin therapy, notably the high-concentration 20% immune globulin subcutaneous solution (Ig20Gly), provides significant advantages, including home administration, reduced systemic adverse reaction (SAR), and enhanced patient autonomy through less frequent dosing and lower infusion volumes. This study aims to evaluate the effectiveness, safety, and treatment satisfaction of Ig20Gly in patients with PID and SID, offering insights into optimizing IGRT and the impact of high-concentration SCIG on improving outcomes. Materials and Methods: The authors conducted a retrospective cohort study of 22 pediatric patients with PID or SID who transitioned from IVIG to SCIG. The authors gathered clinical and demographic data, including infection rates, immunoglobulin G (IgG) levels, school absenteeism, and parental workday loss. Treatment satisfaction was assessed using the treatment satisfaction questionnaire for medication-9, and statistical analyses were performed to compare outcomes before and after the transition. Results: Transitioning to SCIG raised median IgG levels from 690 mg/dL during IVIG to 850 mg/dL after 12 months of SCIG (P <.001). Severe bacterial and lower respiratory tract infections decreased significantly, along with parenteral antibiotic use (P =.003, P =.005, P =.009, respectively). School absenteeism and caregiver workday loss also declined (P <.001). While no SARs were observed with SCIG, mild local reactions were reported, which diminished over time. Treatment satisfaction improved significantly, with younger children under 9 reporting lower convenience scores. Patients on IVIG for over 24 months before SCIG had higher satisfaction scores. Conclusion: Twenty percent SCIG therapy has demonstrated a favorable safety and tolerability profile, providing substantial practical advantages for pediatric patients and their families. This therapy not only streamlines the management of pediatric immunodeficiencies but also effectively maintains optimal Ig levels, thereby decreasing infection rates and improving overall patient well-being. These results underscore the potential of SCIG therapy to enhance treatment satisfaction and quality of life. However, additional research is necessary to confirm these findings and evaluate long-term outcomes.
Eosinophil level, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio as biomarkers of asthma exacerbation
(Mediton Publishing House, 2025) Şenel, Merve Yumrukuz; Karadoğan, Dilek; Kaya, İlknur; Telatar, Tahsin Gökhan; Akgün, Metin
Assessing asthma control and exacerbation risk in patients with asthma are so important to define. Our aim was to explore the relationship between the history of exacerbations in asthmatic patients and key inflammatory markers, namely eosinophil levels, the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR). We also aimed to evaluate the potential of these biomarkers as indicators for asthma exacerbation. Patients with asthma were categorized into two groups based on their exacerbation history, with one group having at least one exacerbation in the last year (Group I) and the other group having none (Group II). The differences in eosinophil, NLR, and PLR values between the two groups were assessed. The mean age of the patients was 52±13 years, and 194 of the 252 asthmatic patients were female (77%). There were 79 (31.6%) patients in Group I and 173 (68.4%) patients in Group II. No statistically significant relationship was found between eosinophil count and asthma exacerbation (p=0.551). However, the NLR and PLR values were significantly higher in Group I (p=0.013 and p=0.002, respectively). In regression analysis, the PLR value was found to be a significant marker for predicting exacerbation. This study revealed higher PLR levels in patients experiencing asthma exacerbations and showed that this parameter significantly predicted exacerbations. Eosinophils and NLR values are not suitable biomarkers for predicting exacerbation risk but can be used to phenotype patients with asthma.
A case of kabuki make-up syndrome type-2 with autism spectrum disorder
(Galenos Publishing House, 2025) Naralan, Yüksel Sümeyra; Naralan, Muhammed Enes
Kabuki make-up syndrome, caused by mutations in the KDM6A gene on chromosome Xp11.23, is a rare genetic disorder characterized by distinct facial features such as outward-turned down lateral eyelids, curved and sparse eyebrows, long palpebral fissures, a flattened wide nose, wide ears, mental disability, skeletal anomalies, postnatal growth retardation, and dermatoglyphic anomalies. In this case of KMS type 2, a fourteen-year-old patient was referred to outpatient clinic by a paediatric neurologist. The patient presented with difficulties in forming relationships, mobility issues, and problems with anger management. Given the presence of dysmorphic facial features, an autism spectrum disorder (ASD) diagnosis, and mental retardation, clinician opted for next-generation genome sequencing, which revealed a de novo mutation in the KMDA6A gene located in the Xp11.3 chromosome region. Although KMS type 2 is a rare genetic syndrome, it is crucial for child psychiatrists to increase their awareness of this condition due to its clinical manifestations, which include ASD and cognitive development delays. This awareness can aid in facilitating early diagnosis and determining the special requirements for managing accompanying comorbid psychiatric conditions and designing tailored educational treatments during follow-up care.
Evaluation of natural radioactivity and radiological risks in baby powders
(Gumushane University, 2025) Dizman, Serdar; Camgöz, Kübra
All living things are constantly exposed to ionizing radiation emitted from natural and artificial radiation sources present in the world throughout their lives. Therefore, it is very important to determine the radioactivity levels of the products that people use and the environment they live in. In this context, 12 baby powder samples of different companies were obtained from local markets. The concentrations of226Ra,232Th and40K in the powder samples were measured using a high purity germanium detector (HPGe). It was determined that226Ra,232Th and40K radioisotope concentrations in the examined powder samples ranged between 2.31-12.71 Bq/kg, 1.26-13.68 Bq/kg and 4.69-38.21 Bq/kg, respectively. The average226Ra,232Th and40K radioactivity concentrations in the powder samples were 5.11 ± 0.81 Bq/kg, 4.17 ± 0.59 Bq/kg and 17.30 ± 1.59 Bq/kg, respectively. To assess the radiological hazards from natural radioisotopes in the examined powder samples, the annual effective dose values (YED) was calculated and compared with the average values recommended by reputable international organizations. As a result, it was determined that the use of the examined powder samples would not pose a radiological risk.
Effect of propolis extracts on OxLDL and LOX-1 Levels in ApoE knockout mice fed a high fat diet
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Korkmaz, Katip; Değer, Orhan; Yiğit, Ertuğrul; Uydu, Hüseyin Avni; Mercantepe, Tolga; Demir, Selim
Atherosclerosis, which has important effects on the development of cardiovascular diseases, is a widespread health problem with the highest mortality rate globally. In this study, we aimed to assess the impact of water and ethanolic extracts of propolis on oxidized low-density lipoprotein (OxLDL) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the progression of the atherosclerotic process, which is characterized by oxidative stress, inflammation, and dyslipidemia. In our study, apolipoprotein E knockout (ApoE−/−) and C57BL/6J mice were used as study groups. Water (WEP) and ethanolic extracts (EEP) of propolis were administered intraperitoneally to ApoE−/− and C57BL/6J mice modeled with a high-fat diet. Under anesthesia, the animals were euthanized by decapitation, and serum, along with aortic tissues, was collected. Serum total cholesterol (TC), triglyceride (TG), OxLDL and LOX-1 levels, OxLDL levels in aortic tissue homogenate, and subendothelial lipid accumulation levels by histological staining were determined in mice and statistical analyses were performed. WEP and EEP supplementation significantly decreased serum TC, TG, OxLDL, LOX-1, and tissue OxLDL levels and reduced plaque burden in the aortic root, with statistically significant differences observed. Those results suggest that propolis extracts have a potential treatment option for atherosclerosis, as a food supplement or a complementary medical/functional food. However, further research is needed to elucidate their molecular mechanisms, evaluate clinical efficacy and safety, and explore possible synergistic effects with existing atherosclerosis treatments.
