Yazar "Cebeci, Yıldız Uygun" için listeleme
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1,2,4-Triazole-conjugated fluoroquinolones as potential candidates for new antibacterial agents
Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Bentham Science Publications, 2024)In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, ... -
Conventional and microwave irradiated synthesis, biological activity evaluation of highly substituted indole-triazole hybrids
Cebeci, Yıldız Uygun; Ceylan, Şule; Karaoğlu, Şengül Alpay (Elsevier, 2022)In the present study, a series of new indole-3-carbaldehyde embedded triazole derivatives have been synthesized. 4-{[(1E)-1H-indol-3-ylmethylidene]amino}-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (2) were converted to ... -
Conventional and microwave-assisted synthesis of novel 1,2,4-triazole derivatives containing tryptamine skeleton and evaluation of antimicrobial activity
Cebeci, Yıldız Uygun; Ceylan, Şule; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Bentham Science Publishing, 2021)1,2,4-Triazole-3-one (3) obtained from tryptamine was transformed to the corresponding carbox(thio)amides via several steps (6a-d). Their reaction with sodium hydroxide performed the 1,2,4triazole derivatives (7a-d). ... -
Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Walter de Gruyter, 2021)4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing ... -
Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Walter de Gruyter, 2021)4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing ... -
An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents
Cebeci, Yıldız Uygun; Ceylan, Şule; Karaoğlu, Şengül Alpay; Altun, Muhammed (Wiley, 2022)1,2,4-Triazole-fluoroquinolone and 1,2,4-triazole-conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized ... -
Microwave-assisted synthesis of novel mannich base and conazole derivatives containing biologically active pharmacological groups
Cebeci, Yıldız Uygun; Ceylan, Şule; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Bentham Science Publishers, 2021)Background: The aim of this study was to synthesize new Mannich bases and conazol derivatives with biological activity by the microwave-assisted method. Introduction: 1,2,4-Triazole-3-one (3) acquired from tryptamine was ... -
Quinolone-rhodanine hybrid compounds: Synthesis and biological evaluation as anti-bacterial agents
Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Wiley, 2022)As potential antimicrobial agents, 4-fluoroaniline and diethyl (ethoxymethylene)malonate were used to efficiently synthesize a new quinolone (3-9) series. The (HNMR)-H-1 and C-13 NMR, IR, mass spectrometry, and elemental ... -
Structure-based hybridization, microwave prompted synthesis and biological evaluation of novel 4-(2-fluoro-4-nitrophenyl)morpholine derivatives
Cebeci, Yıldız Uygun; Demirbaş, Neslihan; Özdemir, Serap Başoğlu; Bayrak, Hacer; Demirbaş, Ahmet; Aksakal, Fatma; Karaoğlu, Şengül Alpay (Bentham Science Publ Ltd, 2018)1,3,4-oxadiazole-2-thiole 6 was obtained from 4-(2-fluoro-4-nitrophenyl)morpholine (2) by the reduction of its nitro group and the sequential treatment of the resulting amine with ethyl bro-moacetate, hydrazine hydrate, ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniques
Ceylan, Şule; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay; Altun, Muhammed (Wiley, 2021)1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a-c). Their reaction with sodium hydroxide gave the 1,2,4-triazole derivatives (7 a-c). ... -
Synthesis of novel antipyrine derivatives possessing remarkable antimicrobial activities
Bayrak, Hacer; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Wiley-V C H Verlag Gmbh, 2019)In this study, new triazole, thiazole, oxazole and Mannich bases were synthesized starting from antipyrine. All the newly synthesized compounds were screened for their antimicrobial activities against some test microorganisms ... -
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
Cebeci, Yıldız Uygun; Bayrak, Hacer; Karaoğlu, Şengül Alpay; Fahim, Asmaa M. (Elsevier, 2022)In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction derivatives that were screened for their antimicrobial activity and compared them with molecular docking and computational Studies. ...
