Yazar "Koca, İrfan" için listeleme
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Design, synthesis, and evaluation of benzimidazole-carbazole hybrids targeting heat shock proteins-mediated apoptosis in breast and colon cancer cells
Çapan, İrfan; Al, Mervenur; Gümüş, Mehmet; Açık, Leyla; Aydın, Betül; Çelik, Ayşe Büşranur; Gülüm, Levent; Sert, Yusuf; Yenilmez, Ezgi Nurdan; Koca, İrfan; Tutar, Yusuf (Wiley, 2025)Heat shock proteins (HSPs), particularly HSP70 and HSP90, are pivotal molecular chaperones implicated in cancer progression and resistance mechanisms. Dual inhibition of these chaperones represents a promising therapeutic ... -
HSP inhibitor sensitize resistant MCF-7 cells to doxorubicin through suppressing HSP90AB4P pseudogene and HSPB1 expression
Coşkun, Kübra Açıkalın; Tutar, Lütfi; Abay, Elif Cansu; Gülüm, Levent; Çelik, Ayşe Büşranur; Gümüş, Mehmet; Koca, İrfan; Tutar, Yusuf (Bentham Science Publishers, 2025)Introduction: Doxorubicin, a first-line chemotherapeutic agent, often faces resistance in breast cancer subtypes, leading to treatment failure. HSPs (Heat shock proteins), especially HSP90, and their pseudogenes like ... -
Synthesis of novel carbazole hydrazine-carbothioamide scaffold as potent antioxidant, anticancer and antimicrobial agents
Çapan, İrfan; Hawash, Mohammed; Qaoud, Mohammed T.; Gülüm, Levent; Tunoğlu, Ezgi Nurdan Yenilmez; Çifci, Kezban Uçar; Çevrimli, Bekir Sıtkı; Sert, Yusuf; Servi, Süleyma; Koca, İrfan; Tutar, Yusuf (BioMed Central Ltd., 2024)Background: Carbazole-based molecules containing thiosemicarbazide functional groups are recognized for their diverse biological activities, particularly in enhancing therapeutic anticancer effects through inhibiting crucial ... -
Synthesis of novel carbazole hydrazine-carbothioamide scaffold as potent antioxidant, anticancer and antimicrobial agents (vol 18, 102, 2024)
Çapan, İrfan; Hawash, Mohammed; Qaoud, Mohammed T.; Gülüm, Levent; Tunoğlu, Ezgi Nurdan Yenilmez; Çifci, Kezban Uçar; Çevrimli, Bekir Sıtkı; Sert, Yusuf; Servi, Süleyman; Koca, İrfan; Tutar, Yusuf (BMC, 2024)........
