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Design, synthesis, and evaluation of benzimidazole-carbazole hybrids targeting heat shock proteins-mediated apoptosis in breast and colon cancer cells
Çapan, İrfan; Al, Mervenur; Gümüş, Mehmet; Açık, Leyla; Aydın, Betül; Çelik, Ayşe Büşranur; Gülüm, Levent; Sert, Yusuf; Yenilmez, Ezgi Nurdan; Koca, İrfan; Tutar, Yusuf (Wiley, 2025)Heat shock proteins (HSPs), particularly HSP70 and HSP90, are pivotal molecular chaperones implicated in cancer progression and resistance mechanisms. Dual inhibition of these chaperones represents a promising therapeutic ...
