Browsing by Author "Emirik, Mustafa"

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Acetate bridged dinuclear Cu(II) complexes with ferrocene based benzimidazol ligands: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

Karaoğlu, Kaan; Emirik, Mustafa; Menteşe, Emre; Zengin, Ali; Serbest, Kerim (Pergamon-Elsevier Science Ltd, 2016)

Two new benzimidazole ligands, 1-[(E)-ferrocenylmethylidenehydrazino]-2-{5,6-dichloro-2-[(o-chloro-phenyl)methyl]-1,3-diaza-1H-inden-1-yl}-1-ethanone (1) and 1-[(E)-ferrocenylmethylidenehydrazino]-2-{2-[p-(trifluoromethy ...
Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors

Mentese, Emre; Emirik, Mustafa; Sokmen, Bahar Bilgin (Academic Press Inc Elsevier Science, 2019)

A novel series of 5,6-dichloro-2-methyl-1H-benzimidazole derivatives was synthesized and then screened for their urease inhibitory activity. All compounds showed more potent inhibitory activity in the range of IC50= 0.0294 ...
Ferrocenyl-substituted dinuclear Cu(II) complex: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

Emirik, Mustafa; Karaoğlu, Kaan; Serbest, Kerim; Menteşe, Emre; Yılmaz, İsmail (Elsevier Science Bv, 2016)

A new ferrocenyl-substituted heterocyclic hydrazide ligand and its Cu(II) complex were prepared. the DFT calculations were performed to determine the electronic and molecular structures of the title compounds. the electronic ...
Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase

Özil, Musa; Emirik, Mustafa; Beldüz, Ali; Ülker, Serdar (Pergamon-Elsevier Science Ltd, 2016)

A series of bisbenzimidazole derivatives starting from o-phenylenediamine and 4-nitro-o-phenylenediamine were prepared with oxalic acid. Most of the reactions were conducted using both the microwave and conventional methods ...
Mononuclear Cu(II) complex of an oxime ligand derived from N-Heterocyclic hydrazide: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

Zengin, Ali; Karaoglu, Kaan; Emirik, Mustafa; Mentese, Emre; Serbest, Kerim (Elsevier Science Bv, 2019)

A new oxime derivative N-heterocyclic hydrazide ligand, N'-[(1E,2E)-2-(hydroxyimino)-1-methylpropylidene]-2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-1)thio] acetohydrazide (1) and its mono-nuclear copper(II) complex (1a) ...
New 1,3,4-thiadiazol derivatives: Synthesis, computational study and X-Ray

Unluer, Dilek; Dugdu, Esra; Emirik, Mustafa; Sahin, Onur; Unver, Yasemin; Sancak, Kemal (Elsevier, 2020)

In this study, 4-hydroxyphenyl-3H-1,2,4-triazol-3-one derivatives (la-d), cyanomethoxyphenyl-3-alkyl/aryl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-acetonitriles (2a-d) and bis amino-1,3,4-thiadiazol-5-alkyl/aryl-2,4-dihydro-3H ...
A novel ferrocenyl naphthoquinone fused crown ether as a multisensor for water determination in acetonitrile and selective cation binding

Dağdevren, Metin; Yılmaz, İsmail; Yücel, Barış; Emirik, Mustafa (Amer Chemical Soc, 2015)

A multisensor which is based on a novel multifunctional triad molecule, ferrocenyl naphthoquinone fused crown ether (Fc-cnq) bearing ferrocene, quinone, and crown ether functional groups together, was synthesized and ...
Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation

Demir, Adem; Turumtay, Halbay; Emirik, Mustafa; SandalIi, Cemal; Kanbolat, Seyda; Ozgen, Ufuk; Turumtay, Emine Akyuz (Springer Birkhauser, 2019)

The methanolic extracts from fruit, leaf, stem and roots of Paeonia daurica subsp. macrophylla (P. daurica) were investigated for inhibitory effect on replicative bacterial (PolC and DnaE2) and viral (MMLV-RT from Moloney ...
Potential therapeutic effect of turmeric contents against SARS-CoV-2 compared with experimental COVID-19 therapies: in silico study

Emirik, Mustafa (Taylor & Francis Inc, 2020)

Inspired by the 'There is no scientific evidence that turmeric prevents COVID-19' statement made by WHO, the protective or therapeutic potential of the compounds in turmeric contents was investigated against COVID-19 with ...
A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies

Özil, Musa; Emirik, Mustafa; Etlik, Semiha Yılmaz; Ülker, Serdar; Kahveci, Bahittin (Academic Press Inc Elsevier Science, 2016)

A novel series of benzimidazole derivatives were prepared starting from o-phenylenediamine and 4-nitro-o-phenylenediamine with iminoester hydrochlorides. Acidic proton in benzimidazole was exchanged with ethyl bromoacetate, ...
Spectroscopic, electrochemical, theoretical characterization and biological evaluation of a ferrocenyl-substituted unsymmetric azine ligand and its Cu(II) complex

Özel, Arzu; Karaoğlu, Kaan; Serbest, Kerim; Gürcan, Nihan; Emirik, Mustafa; Coruh, Ufuk (Taylor & Francis Ltd, 2016)

Ferrocenyl-substituted unsymmetrical azine and its Cu(II) complex were prepared. the redox active ferrocene-based azine was obtained by condensation of 1-[(E)-hydrazono]-5-bromo-2-hydroxybenzene with ferrocene carboxaldehyde. ...
Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies

Mentese, Emre; Guner, Adem; Polatli, Elifsu; Emirik, Mustafa; Bektas, Hakan; Kahveci, Bahittin (Wiley-V C H Verlag Gmbh, 2020)

The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. the newly synthesized compounds were screened for their in ...
Synthesis and characterization of two new hydroxamic acids derivatives and their metal complexes. An investigation on the keto/enol, E/Z and hydroxamate/hydroxirnate forms

Adiguzel, Ekrem; Yilmaz, Fatih; Emirik, Mustafa; Ozil, Musa (Elsevier Science Bv, 2017)

2-phenylbenzimidazole-N-acetohydroxamic acid (HL1), 2-phenylbenzimidazole-N-butanohydroxamic acid (HL2) and Ni(II), Cu(II), Zn(II) and Cd(II) metal complexes have been synthesized and characterized by elemental analyses, ...
Synthesis and Molecular Docking Studies of Novel Triazole Derivatives as Antioxidant Agents

Ozil, Musa; Tacal, Guvan; Baltas, Nimet; Emirik, Mustafa (Bentham Science Publ Ltd, 2020)

A series of 1,2,4-triazole and 1,2,4- thiadiazole derivatives were prepared starting from ethyl 4-(3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzoate. Firstly, both ethyl ester groups were simultaneously transformed ...
Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease

Mentese, Emre; Bektas, Hakan; Sokmen, Bahar Bilgin; Emirik, Mustafa; Cakir, Demet; Kahveci, Bahittin (Pergamon-Elsevier Science Ltd, 2017)

A new series of benzimidazole compounds including hydrazinecarbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole and imine function were synthesized starting from 5,6-dichloro-2-cyclopropyl-1H-benzimidazole. All of the benzimidazole ...
Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease

Akyuz, Gulay; Mentese, Emre; Emirik, Mustafa; Baltas, Nimet (Academic Press Inc Elsevier Science, 2018)

A new series of 2,3-disubstituted quinazolin-4(3H)-one compounds including oxadiazole and furan rings was synthesized. Their inhibitory activities on urease were assessed in vitro. All newly synthesized compounds exhibited ...
Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

Mermer, Arif; Bayrak, Hacer; Sirin, Yakup; Emirik, Mustafa; Demirbas, Neslihan (Elsevier Science Bv, 2019)

This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. the synthesized compounds were evaluated for in ...
Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors

Mentese, Emre; Akyuz, Gulay; Yilmaz, Fatih; Baltas, Nimet; Emirik, Mustafa (Wiley-V C H Verlag Gmbh, 2018)

A new series of quinazolinone hybrid molecules containing coumarin, furan, 1,2,4-triazole and 1,2,4-thiadiazole rings was designed, synthesized, and screened for their urease inhibition activities. All newly synthesized ...
Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives

Mentese, Emre; Baltas, Nimet; Emirik, Mustafa (Academic Press Inc Elsevier Science, 2020)

In this study, a new series of 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives has been synthesized and screened for their alpha-glucosidase inhibitory potential. All molecules showed a considerable ...
Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities

Mentese, Emre; Akyuz, Gulay; Emirik, Mustafa; Baltas, Nimet (Academic Press Inc Elsevier Science, 2019)

A new series of quinazolinone derivatives containing triazole, thiadiazole, thiosemicarbazide functionalities was synthesized and then screened for their in vitro urease inhibition properties. Most of the compounds showed ...

Browsing by Author "Emirik, Mustafa"

Acetate bridged dinuclear Cu(II) complexes with ferrocene based benzimidazol ligands: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity ﻿

Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors ﻿

Ferrocenyl-substituted dinuclear Cu(II) complex: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity ﻿

Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase ﻿

Mononuclear Cu(II) complex of an oxime ligand derived from N-Heterocyclic hydrazide: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity ﻿

New 1,3,4-thiadiazol derivatives: Synthesis, computational study and X-Ray ﻿

A novel ferrocenyl naphthoquinone fused crown ether as a multisensor for water determination in acetonitrile and selective cation binding ﻿

Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation ﻿

Potential therapeutic effect of turmeric contents against SARS-CoV-2 compared with experimental COVID-19 therapies: in silico study ﻿

A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies ﻿

Spectroscopic, electrochemical, theoretical characterization and biological evaluation of a ferrocenyl-substituted unsymmetric azine ligand and its Cu(II) complex ﻿

Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies ﻿

Synthesis and characterization of two new hydroxamic acids derivatives and their metal complexes. An investigation on the keto/enol, E/Z and hydroxamate/hydroxirnate forms ﻿

Synthesis and Molecular Docking Studies of Novel Triazole Derivatives as Antioxidant Agents ﻿

Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease ﻿

Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease ﻿

Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies ﻿

Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors ﻿

Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives ﻿

Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities ﻿

Acetate bridged dinuclear Cu(II) complexes with ferrocene based benzimidazol ligands: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors

Ferrocenyl-substituted dinuclear Cu(II) complex: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase

Mononuclear Cu(II) complex of an oxime ligand derived from N-Heterocyclic hydrazide: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity

New 1,3,4-thiadiazol derivatives: Synthesis, computational study and X-Ray

A novel ferrocenyl naphthoquinone fused crown ether as a multisensor for water determination in acetonitrile and selective cation binding

Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation

Potential therapeutic effect of turmeric contents against SARS-CoV-2 compared with experimental COVID-19 therapies: in silico study

A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies

Spectroscopic, electrochemical, theoretical characterization and biological evaluation of a ferrocenyl-substituted unsymmetric azine ligand and its Cu(II) complex

Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies

Synthesis and characterization of two new hydroxamic acids derivatives and their metal complexes. An investigation on the keto/enol, E/Z and hydroxamate/hydroxirnate forms

Synthesis and Molecular Docking Studies of Novel Triazole Derivatives as Antioxidant Agents

Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease

Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease

Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors

Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives

Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities