Browsing by Author "Kalkan, Y."

The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells

Kalkan, Y.; Bostan, H.; Tumkaya, L.; Tomak, Y.; Bostan, M.; Yilmaz, A.; Yalçin, A. (0-Belirlenecek, 2012)

Purpose: Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of ...

The effect of royal jelly on CD3+, CD5+, CD45+ T-cell and CD68+ cell distribution in the colon of rats with acetic acid-induced colitis

Karaca, T.; Şimşek, N.; Uslu, S.; Kalkan, Y.; Can, I.; Kara, A.; Yörük, M. (0-Belirlenecek, 2012)

Background: Traditional medicines and health supplements have historically been used to treat many illnesses but most of them have not been evaluated objectively to prove their efficacy. We have been investigating the ...

Effects of diabetes and ovariectomy on rat hippocampus (A biochemical and stereological study)

Altunkaynak, B.Z.; Unal, D.; Altunkaynak, M.E.; Halici, Z.; Kalkan, Y.; Keles, O.N.; Unal, B. (0-Belirlenecek, 2012)

Oxidative stress is one of the main reasons of both menopause and diabetes. So, it plays crucial role in the pathogeneses of that condition and disease. Therefore, the objective of the present study was to investigate the ...

Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: An immunohistochemical study

Simsek, N.; Kaya, M.; Kara, A.; Can, I.; Karadeniz, A.; Kalkan, Y. (0-Belirlenecek, 2012)

This investigation was carried out to explore the antidiabetic, antiapoptotic and neogenetic effects of melatonin (MLT) in streptozotocin-induced diabetic rats. Sixty-four male rats were assigned randomly to one of four ...

Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver

Tomak, Y.; Yälmaz, A.; Bostan, H.; Tümkaya, L.; Altuner, D.; Kalkan, Y.; Erdivanlä, B. (0-Belirlenecek, 2012)

We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ...

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: A pilot study

Kalkan, Y.; Tümkaya, L.; Bostan, H.; Tomak, Y.; Yilmaz, A. (0-Belirlenecek, 2012)

Reversal of neuromuscular blockage induced by steroidal neuromuscular blocking agents such as rocuronium can be achieved using normal dose of sugammadex, which has been shown to be very effective for such reversal. In this ...

Hepatic effects of ketamine administration for 2 weeks in rats

Kalkan, Y.; Tomak, Y.; Altuner, D.; Tumkaya, L.; Bostan, H.; Yilmaz, A.; Turan, A. (0-Belirlenecek, 2014)

The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ...

Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats

Kara, A.; Akman, S.; Ozkanlar, S.; Tozoglu, U.; Kalkan, Y.; Canakci, C.F.; Tozoglu, S. (0-Belirlenecek, 2013)

Melatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration. Periodontitis is a disease of the oral cavity and the ...

Is adalimumab protective in ischemia?reperfusion injury in lung?

Kurt, A.; Tumkaya, L.; Kalkan, Y.; Turut, H.; Cure, M.C.; Cure, E.; Usta, M. (Mashhad University of Medical Sciences, 2015)

Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I?R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor?alpha (TNF??) inhibitor agent. We aimed ...

Lasting hepatotoxic effects of prenatal mobile phone exposure

Yilmaz, A.; Tumkaya, L.; Akyildiz, K.; Kalkan, Y.; Bodur, A. F.; Sargin, F.; Yazici, Z. A. (Taylor & Francis Ltd, 2017)

Objective: in this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.Methods: Pregnant rats were exposed to ...

Numerical analysis of age and gender-dependent neuronal cells in postnatal development of rat hippocampus

Kalkan, Y.; Unal, B.; Keles, O.N.; Kara, A. (0-Belirlenecek, 2013)

The hippocampus, phylogenetically one of the most ancient parts of the central nervous system, is both a highly developed structure of the mammalian brain that plays a role in complex brain functions and one of the brain ...

Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate

Kalkan, Y.; Kapakin, K.A.T.; Kara, A.; Atabay, T.; Karadeniz, A.; Simsek, N.; Sengul, E. (0-Belirlenecek, 2012)

The protective effects of Panax ginseng (PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague- Dawley rats were randomly divided into 4 equal groups and treated ...

A reply

Tomak, Y.; Erdivanli, B.; Kalkan, Y.; Tumkaya, L. (0-Belirlenecek, 2013)

[No abstract available]

Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys

Bostan, H.; Kalkan, Y.; Tomak, Y.; Tumkaya, L.; Altuner, D.; Yilmaz, A.; Bedir, R. (0-Belirlenecek, 2011)

Background: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six ...