Browsing by Author "Ulker, Serdar"
Now showing items 1-5 of 5
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Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids
Mermer, Arif; Demirci, Serpil; Ozdemir, Serap Basoglu; Demirbas, Ahmet; Ulker, Serdar; Ayaz, Faik Ahmet; Demirbas, Neslihan (Elsevier Science Inc, 2017)Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing beta-lactame or flouroquinolone core via a one pot three component reaction. the ... -
Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents
Kahveci, Bahittin; Yilmaz, Fatih; Mentese, Emre; Ulker, Serdar (Wiley-V C H Verlag Gmbh, 2017)The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation ... -
Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin
Demirci, Serpil; Aksakal, Fatma; Colak, Nesrin; Ulker, Serdar; Demirbas, Ahmet; Demirbas, Neslihan (Bentham Science Publ Ltd, 2017)Background: the amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave ... -
Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and alpha-glucosidase inhibition
Bekircan, Olcay; Ulker, Serdar; Mentese, Emre (Taylor & Francis Ltd, 2015)In the present study, 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide (1) was used as starting compound for the synthesis of 2-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl ... -
Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
Mentese, Emre; Yilmaz, Fatih; Emirik, Mustafa; Ulker, Serdar; Kahveci, Bahittin (Academic Press Inc Elsevier Science, 2018)In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. ...
