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Toplam kayıt 25, listelenen: 21-25
The effects of dexmedetomidine on abdominal aortic occlusion-induced ovarian injury via oxidative stress and apoptosis
(Karger, 2023)
Ischemia/reperfusion (IR) induced ovarian damage is caused by various diseases such as ovarian torsion, ovarian transplantation, cardiovascular surgery, sepsis, or intra-abdominal surgery. I/R-related oxidative damage can ...
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
(Elsevier, 2023)
Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely
used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ...
N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats
(Marmara Üniversitesi, 2023)
Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is ...
Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress
(Elsevier, 2024)
It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, ...
Arbutin abrogates cisplatin-induced hepatotoxicity via upregulating Nrf2/HO-1 and suppressing genotoxicity, NF-κB/iNOS/TNF-α and caspase-3/Bax/Bcl2 signaling pathways in rats
(Oxford University Press, 2024)
Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated the hepatoprotective mechanism ...