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The role of RAAS inhibition by aliskiren on paracetamol-induced hepatotoxicity model in rats

Karcıoğlu, Saliha Sena; Palabıyık, Şaziye Sezin; Bayır, Yasin; Karakuş, Emre; Mercantepe, Tolga; Halıcı, Zekai; Albayrak, Abdulmecit (Wiley, 2016)

Paracetamol is one of the most popular and widely used analgesic and antipyretic agents, but an overdose can cause hepatotoxicity and lead to acute liver failure. Aliskiren directly inhibits renin which downregulates the ...

Protective effect of an L-type calcium channel blocker, amlodipine, on paracetamol-induced hepatotoxicity in rats

Kaya, Habibe Budak; Polat, Beyzagül; Albayrak, Aabdulmecit; Mercantepe, Tolga; Büyük, Başak (Sage Publications Ltd, 2018)

Paracetamol (P), one of the most popular and commonly used analgesic and antipyretic agents, causes hepatotoxicity in overdoses. Amlodipine (AML), an L-type calcium channel blocker, has been shown to have anti-inflammatory ...