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Synthesis of novel 2,3-disubstituted quinazolin-4(3H)-one derivatives containing hydrazone skeleton as potent urease inhibitors and their antimicrobial activities 

Akyuz, Gulay; Beris, Fatih Saban; Kahveci, Bahittin; Mentese, Emre (Wiley, 2019)
A new series of quinazolinones containing hydrazone moiety were synthesized, and their inhibitory activities on urease were assessed in vitro. Most of the compounds exhibited potent urease inhibitory activity. Among the ...

SYNTHESIS, INHIBITORY PROPERTIES ON THE METABOLIC ENZYMES AND ANTIOXIDANT ACTIVITY OF A NEW SERIES BENZIMIDAZOLE DERIVATIVES 

Karaali, Nesrin; Atik, Ridvan; Balta, Nimet; Sasmaz, Selami; Kahveci, Bahittin (Editura Acad Romane, 2019)
In this study, a series of new 1, 2-disubstituted benzimidazole was synthesized starting from 5, 6-dichloro-2-(4-methoxybenzyl)-1H-benzimidazole compound which was converted to the ester and hydrazide derivative, respectively. ...

Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies 

Mentese, Emre; Guner, Adem; Polatli, Elifsu; Emirik, Mustafa; Bektas, Hakan; Kahveci, Bahittin (Wiley-V C H Verlag Gmbh, 2020)
The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. the newly synthesized compounds were screened for their in ...

Synthesis and evaluation of alpha-glucosidase and pancreatic lipase inhibition by quinazolinone-coumarin hybrids 

Mentese, Emre; Karaali, Nesrin; Akyuz, Gulay; Yilmaz, Fatih; Ulker, Serdar; Kahveci, Bahittin (Springer, 2016)
A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and a-glucosidase inhibition properties. Among the synthesized compounds, ...

Microwave Assisted Synthesis of Cournarins: A Review From 2007 to 2018 

Kahveci, Bahittin; Mentese, Emre (Bentham Science Publ Ltd, 2018)
Background: Microwave heating has been shown to be an invaluable technology for medicinal chemistry and drug discovery applications. Recently, it has been used for heterocyclic synthesis increasingly. This review article ...

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW TRIAZOLE BRIDGED BENZIMIDAZOLE SUBSTITUTED PHTHALONITRILE AND PHTHALOCYANINES 

Kantar, Gunay Kaya; Mentese, Emre; Beris, Fatih Saban; Sasmaz, Selami; Kahveci, Bahittin (Editura Acad Romane, 2018)
In this study, some new phthalonitriles and metallophthalocyanines (Zn, Ni, Co, and Cu) containing triazole bridged benzimidazole moieties were synthesized starting from 2-(3-methylbenzyl)-1H-benzimidazole Newly synthesized ...

Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors 

Mentese, Emre; Yilmaz, Fatih; Emirik, Mustafa; Ulker, Serdar; Kahveci, Bahittin (Academic Press Inc Elsevier Science, 2018)
In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. ...

Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents 

Kahveci, Bahittin; Yilmaz, Fatih; Mentese, Emre; Ulker, Serdar (Wiley-V C H Verlag Gmbh, 2017)
The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation ...

Efficient Synthesis of Benzimidazoles Containing 1,2,4-Triazol-3-One Nucleus Using Microwave Technique 

Mentese, Emre; Kahveci, Bahittin (Springer, 2016)
A series of new compounds containing both benzimidazole and 1,2,4-triazol-3-one rings was synthesized by microwave irradiation of mixtures containing 5-(alkyl/phenyl)-4-(4-carboxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones ...

Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease 

Mentese, Emre; Bektas, Hakan; Sokmen, Bahar Bilgin; Emirik, Mustafa; Cakir, Demet; Kahveci, Bahittin (Pergamon-Elsevier Science Ltd, 2017)
A new series of benzimidazole compounds including hydrazinecarbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole and imine function were synthesized starting from 5,6-dichloro-2-cyclopropyl-1H-benzimidazole. All of the benzimidazole ...
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